ChemicalBook Product Catalog Catalyst and Auxiliary polymer Biotin-PEG3-CH2COOH

Biotin-PEG3-CH2COOH

Biotin-PEG3-CH2COOH Basic information
Product Name:Biotin-PEG3-CH2COOH
Synonyms:Biotin-PEG3-acetic Acid;13-oxo-17-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecanoic acid;Biotin-PEG3-CH2COOH;CAS_1189560-96-0;3,6,9-Trioxa-12-azaheptadecanoic acid, 17-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-13-oxo-;11-(Biotinamido)-3,6,9-trioxaundecanoic Acid;13-oxo-17-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9-trioxa-12-azaheptadecan-1-oic acid;Biotin-PEG3-CH2COOH/3,6,9-Trioxa-12-azaheptadecanoic acid, 17-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-13-oxo-
CAS:1189560-96-0
MF:C18H31N3O7S
MW:433.52
EINECS:
Product Categories:peg
Mol File:1189560-96-0.mol
Biotin-PEG3-CH2COOH Structure
Biotin-PEG3-CH2COOH Chemical Properties
Safety Information
MSDS Information
Biotin-PEG3-CH2COOH Usage And Synthesis
Biological ActivityBiotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Biotin-PEG3-CH2COOH Preparation Products And Raw materials
Biotin-PEG3-propargyl Biotin-PEG5-SH 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester Biotinyl-AEEA 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)- Biotin-PEG20000-maleimide Biotin-PEG5-Amine Biotin-PEG4-NH2 HCl
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