Chlorosulfonyl isocyanate

Chlorosulfonyl isocyanate Basic information
Product Name:Chlorosulfonyl isocyanate
Synonyms:N-(Oxomethylidene)sulfamoyl chloride;N-Chlorosulphonyl isocyanate;Chlorosulfonyl isocyanate ,99%;Chlorosulfonyl isocyanate,N-Carbonylsulfamyl chloride, CSI;Chlorosulfonyl isocy;Chlorosulfonyl isocyanate, 98+% 50ML;Chlorosulfonyl isocyanate, 98+% 5ML;Sulfonyl chloride isocyanate
CAS:1189-71-5
MF:CClNO3S
MW:141.53
EINECS:214-715-2
Product Categories:Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;Cyanogen chloride derivatives;Hydrocyanic acid derivatives;Pharmaceutical Intermediates
Mol File:1189-71-5.mol
Chlorosulfonyl isocyanate Structure
Chlorosulfonyl isocyanate Chemical Properties
Melting point -44 °C (lit.)
Boiling point 107 °C (lit.)
density 1.626 g/mL at 25 °C (lit.)
vapor pressure 5.57 psi ( 20 °C)
refractive index n20/D 1.447(lit.)
Fp >110°C
storage temp. 2-8°C
solubility Chloroform (Slightly, Heated)
form Crystals, Crystalline Powder or Granules
Specific Gravity1.626 (20℃)
color White
Water Solubility reacts violently exothermic
BRN 1237247
CAS DataBase Reference1189-71-5(CAS DataBase Reference)
EPA Substance Registry SystemSulfuryl chloride isocyanate (1189-71-5)
Safety Information
Hazard Codes C
Risk Statements 14-22-34-42-20/22
Safety Statements 23-26-30-36/37/39-45
RIDADR UN 3265 8/PG 2
WGK Germany 3
10-21-19
HazardClass 8
PackingGroup II
HS Code 28510080
ToxicityLD50 orally in Rabbit: 640 mg/kg
MSDS Information
ProviderLanguage
N-Carbonylsulfamyl chloride English
SigmaAldrich English
ACROS English
Chlorosulfonyl isocyanate Usage And Synthesis
Chemical PropertiesClear liquid, colourless
UsesChlorosulfonyl isocyanate, a highly reactive chemical for chemical synthesis, is used as an intermediate used for production of antibiotics (Cefuroxime, penems), polymers as well as agrochemicals. Product Data Sheet
UsesEmployed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines. Generation of ureas from amino groups in a synthesis of benzimidazolones.
General DescriptionChlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams.
Chlorosulfonyl isocyanate Preparation Products And Raw materials
Preparation Products4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE-->1H-Pyrrole-3-carbonitrile,2,5-dimethyl-(9CI)-->Imidodisulfurylchloride-->TRIFLUOROACETYL ISOCYANATE,-->1-Methylpyrrole-2-carbonitrile-->Precursor of cefcapene diisopropylanmine salt-->tert-butyl 2-cyano-1H-pyrrol-1-ylcarbaMate-->2,4-Dihydroxythieno[2,3-d]pyrimidine-->5-Bromo-3-cyanoindole-->Cyclobutanecarbonitrile-->4-Acetoxy-2-azetidinone-->PYRROLE-2-CARBONITRILE-->Benzamide, N-(chlorosulfonyl)-
Isopropyl isocyanate ISOCYANIC ACID trans-4-Methycyclohexyl isocyanate Hexyl isocyanate Sulfosulfuron BENZOYL ISOCYANATE Benzyl isocyanate Calcium chloride Tosylmethyl isocyanide ISOCYANATE Choline chloride Ammonium chloride p-Toluenesulfonyl Isocyanate Chlorosulfonyl isocyanate Potassium chloride Thionyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile Phenylmethylsulfonyl fluoride

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