insoluble in H2O; ≥1 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.45 mg/mL in DMSO
pka
12.19±0.43(Predicted)
form
powder
color
white to beige
Safety Information
MSDS Information
PD168393 Usage And Synthesis
Uses
PD 168393, is an irreversible epidermal growth factor receptor (EGFR) inhibitor.
Uses
PD168393 has been used in the acute inhibition of ErbB4.
Definition
ChEBI: A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.
Biochem/physiol Actions
PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
