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| Product Name: | BMH21 | | Synonyms: | BMH21;N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;CS-1749;BMH 21;BMH21;BMH-21, >98%;12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo- | | CAS: | 896705-16-1 | | MF: | C21H20N4O2 | | MW: | 360.41 | | EINECS: | 809-833-1 | | Product Categories: | Inhibitors | | Mol File: | 896705-16-1.mol |  |
| | BMH21 Chemical Properties |
| density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble1mg/mL, clear (warmed) | | form | powder | | pka | 7.90±0.20(Predicted) | | color | light yellow to dark yellow |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | BMH21 Usage And Synthesis |
| Uses | BMH-21 has been used in cell culture. | | General Description | BMH-21 is a planar heterocyclic small molecule DNA intercalator. | | Biochem/physiol Actions | BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines. | | storage | Store at -20°C |
| | BMH21 Preparation Products And Raw materials |
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