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| | TYRPHOSTIN A51 Basic information |
| Product Name: | TYRPHOSTIN A51 | | Synonyms: | AG 183;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE;TYRPHOSTIN AG 183;TYRPHOSTIN A51;TYRPHOSTIN 51;2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE;1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)- | | CAS: | 122520-90-5 | | MF: | C13H8N4O3 | | MW: | 268.23 | | EINECS: | | | Product Categories: | | | Mol File: | 122520-90-5.mol |  |
| | TYRPHOSTIN A51 Chemical Properties |
| Melting point | 275 °C | | Boiling point | 788.2±60.0 °C(Predicted) | | density | 1.591±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | Orange solid. | | pka | 8.46±0.15(Predicted) |
| WGK Germany | 3 | | HazardClass | 6.1 |
| | TYRPHOSTIN A51 Usage And Synthesis |
| Description | Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. | | Uses | Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3.. | | Definition | ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol. | | references | [1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398. |
| | TYRPHOSTIN A51 Preparation Products And Raw materials |
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