2-CHLOROETHANESULFONYL CHLORIDE

2-CHLOROETHANESULFONYL CHLORIDE Basic information

Product Name:	2-CHLOROETHANESULFONYL CHLORIDE
Synonyms:	2-Chloroethane-1-sulfonic acid chloride;2-Chloroethanesulfonic acid chloride;2-Chloroethanesulfonyl Chloride, 95.0%(GC&T;2-CHLOROETHANESULFONYL CHLORIDE;2-CHLOROETHANESULPHONYL CHLORIDE;2-CHLORO-1-ETHANESULFONYL CHLORIDE;beta-chloroethanesulfonylchloride;beta-chloroethanesulfonylchloride[qr]
CAS:	1622-32-8
MF:	C2H4Cl2O2S
MW:	163.02
EINECS:	216-594-1
Product Categories:	Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;Others;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Protecting and Derivatizing Reagents;Protection and Derivatization
Mol File:	1622-32-8.mol

2-CHLOROETHANESULFONYL CHLORIDE Chemical Properties

Melting point	3 °C
Boiling point	84-86 °C15 mm Hg(lit.)
density	1.56 g/mL at 25 °C(lit.)
vapor pressure	15 mm Hg ( 84 °C)
refractive index	n20/D 1.493(lit.)
Fp	>230 °F
storage temp.	Refrigerator
form	Liquid
color	Clear slightly yellow to brown
Water Solubility	Reacts with water.
Sensitive	Moisture Sensitive
BRN	1751202
CAS DataBase Reference	1622-32-8(CAS DataBase Reference)
EPA Substance Registry System	2-Chloro-ethanesulfonyl chloride (1622-32-8)

Safety Information

Hazard Codes	T+
Risk Statements	22-26-34-36
Safety Statements	26-28-36/37/39-45-23
RIDADR	UN 3390 6.1/PG 1
WGK Germany	3
RTECS	KI8060000
F	10-19
TSCA	Y
HazardClass	8
PackingGroup	II
HS Code	29049090
Hazardous Substances Data	1622-32-8(Hazardous Substances Data)
Toxicity	mouse,LC50,inhalation,250mg/m3/4H (250mg/m3),Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(6), Pg. 59, 1971.

MSDS Information

2-CHLOROETHANESULFONYL CHLORIDE Usage And Synthesis

Chemical Properties	CLEAR SLIGHTLY YELLOW TO BROWN LIQUID
Uses	2-Chloroethanesulfonyl chloride was used in one-pot sulfonylation/intramolecular thia-Michael protocol for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. It was also used in synthesis of vinyl sulfonamides with a furan, carbocyclic, semi cyclic or acyclic 1,3-diene moiety.
General Description	A liquid. Density 1.56 g / cm3. Flash point exceeds 230°F.
Air & Water Reactions	Reacts with water to produce corrosive and toxic gaseous hydrogen chloride.
Reactivity Profile	2-CHLOROETHANESULFONYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

2-CHLOROETHANESULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials	Phosphorothioic acid, S-(2-chloroethyl) O,O-diethyl ester-->Sodium isethionate-->2-Hydroxyethanesulphonic acid-->2-Chloroethylamine hydrochloride-->2,2'-Thiodiethanol-->2-Mercaptoethanol
Preparation Products	Sodium ethylenesulphonate-->N-(3-methoxyphenyl)-2-morpholin-4-yl-2-oxo-acetamide-->Ethenesulfonic acid, 1-methylethyl ester-->EthenesulfonaMide, N,N-bis(phenylMethyl)-->1-Piperazinecarboxylic acid, 4-(ethenylsulfonyl)-, phenylmethyl ester-->N-benzylethenesulfonamide-->1-(Vinylsulfonyl)piperidine

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