2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile

2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Basic information
Product Name:2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
Synonyms:2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile;Erlotinib Hydrochloride iMpurity 23;2-((4-chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol;Benzonitrile, 2-amino-4,5-bis(2-methoxyethoxy)-;Erlotinib Impurity 134
CAS:950596-58-4
MF:C13H18N2O4
MW:266.29
EINECS:1308068-626-2
Product Categories:
Mol File:950596-58-4.mol
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Structure
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Chemical Properties
Melting point 73-77 °C
Boiling point 445.5±45.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka1.85±0.10(Predicted)
color Pale Beige to Beige
Safety Information
MSDS Information
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Usage And Synthesis
Uses2-((4-Chloro-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol is an impurity if Erlotinib (E625008) a EGFR-targeted drug in the treatment of non-small cell lung cancer.
Uses2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile Preparation Products And Raw materials
Preparation ProductsErlotinib
Ethyl 3,4-dihydroxybenzoate 4-Quinazolinamine,N-(3-ethenylphenyl)-6,7-bis(2-methoxyethoxy)-,hydrochloride(1:1) Erlotinib Imp.15 Erlotinib Imp.5 Erlotinib Impurity 30 Erlotinib Impurity 1 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 4-CHLORO-7-(2-CHLORO-ETHOXY)-6-(2-METHOXY-ETHOXY)-QUINAZOLINE Ethyl 3,4-bis(2-methoxyethoxy)benzoate OSI-420 2-ETHYNYLANILINE 98 DesMethyl Erlotinib Carboxylate Acid 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)- OSI-420 4-QuinazolinaMine, 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-Methoxyethoxy)- Erlotinib iMpurity 2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride Erlotinib

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