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Sultopride hydrochloride

Sultopride hydrochloride Basic information
Product Name:Sultopride hydrochloride
Synonyms:n-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-ethylsulfonylbenzamidehydroch;MS-5024;Stadorf;Einecs 245-829-0;N-((1-Ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride;Sultopride hydrochloride (LIN-1418 hydrochloride);N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-benzamidhyd
CAS:23694-17-9
MF:C17H27ClN2O4S
MW:390.93
EINECS:245-829-0
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:23694-17-9.mol
Sultopride hydrochloride Structure
Sultopride hydrochloride Chemical Properties
Melting point 181-182°C
storage temp. Sealed in dry,Room Temperature
solubility Acetonitrile (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Safety Information
MSDS Information
Sultopride hydrochloride Usage And Synthesis
Chemical PropertiesCrystalline Solid
OriginatorBarnetil,Delagrange,France,1976
UsesDopamine D2-receptor antagonist. An antipsychotic.
Manufacturing ProcessA solution of 17.22 g of N-ethyl-α-aminomethylpyrrolidine in 360 ml of pyridine is placed in a 1 l balloon flask. A solution of 3.51 g of phosphorus trichloride in 40 ml of pyridine is added at ambient temperature. After the mixture has been stirred for 1 hour, 10 g of 2-methoxy-5-ethylsulfonylbenzoic acid is introduced. The mixture is heated under reflux for 4 ? hours. After cooling, the solvent is evaporated under vacuum and the residue is dissolved in 200 ml of 20% sodium hydroxide. The solution is extracted with 200 ml of chloroform.
The organic solution is dried and filtered and the solvent is evaporated under vacuum; the residue is dissolved in 150 ml of ethanol and the solution is acidified with hydrochloric acid. The hydrochloride is dried without heating and recrystallized from 100 ml of absolute ethanol. 7.2 g of N-(1-ethyl-2- pyrrolidyl-methyl-2-methoxy-5-ethylsulfonylbenzamide hydrochloride is produced. Melting point: 190°C to 193°C.
Therapeutic FunctionNeuroleptic
Sultopride hydrochloride Preparation Products And Raw materials
Raw materialsPyrrolidine-->Phosphorus trichloride-->2-Methoxy-5-(ethylsulfonyl)benzoic acid
Chlorantraniliprole Methylparaben Tiapride hydrochloride SULTOPRIDE-D5 Bensulfuron methyl Amisulpride-d5 Parathion-methyl Topotecan hydrochloride Kresoxim-methyl Benzamide Thiophanate-methyl Itopride hydrochloride Amisulpride PYRROLIDONE HYDROTRIBROMIDE Sultopride hydrochloride Methyl acrylate Methyl acetate METSULFURON METHYL
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