2-Trifluoromethyl-5-bromopyridine

2-Trifluoromethyl-5-bromopyridine Basic information

Product Name:	2-Trifluoromethyl-5-bromopyridine
Synonyms:	5-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE;2-TRIFLUOROMETHYL-5-BROMOPYRIDINE;5-Bromo-2-(trifluoromethyl)pyridine 97%;5-Bromo-2-(trifluoromethyl)pyridine97%;3-Bromo-6-(trifluoromethyl) pyridine;TRIFLUOROMETHYL-5-BROMOPYRIDINE;TRIFLUOROMETHYL-5-BROMO-2-PYRIDINE;5-Bromo-alpha,alpha,alpha-trifluoro-2-picoline
CAS:	436799-32-5
MF:	C6H3BrF3N
MW:	225.99
EINECS:
Product Categories:	Fluorine series;C6Heterocyclic Building Blocks;Heterocyclic Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;blocks;Bromides;FluoroCompounds;Pyridines;Pyridine Series;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine;Heterocycle;Halides;Heterocycles;436799-32-5
Mol File:	436799-32-5.mol

2-Trifluoromethyl-5-bromopyridine Chemical Properties

Melting point	44-46 °C
Boiling point	68-70°C 10mm
density	1.707±0.06 g/cm3(Predicted)
Fp	174 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	-1.80±0.22(Predicted)
color	White to Almost white
CAS DataBase Reference	436799-32-5(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

2-Trifluoromethyl-5-bromopyridine Usage And Synthesis

Chemical Properties	white crystal powder
Uses	Regioselective C-4 deprotonation with LDA and trapping with carbon dioxide leads to the corresponding C-4 acid.

2-Trifluoromethyl-5-bromopyridine Preparation Products And Raw materials

Raw materials	Diethyl ether-->Ammonia-->Potassium fluoride-->N-Methyl-2-pyrrolidone-->Cuprous iodide-->(Trifluoromethyl)trimethylsilane-->2,5-Dibromopyridine-->Copper, (trifluoromethyl)--->5-Amino-2-(trifluoromethyl)pyridine-->Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate
Preparation Products	6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE-->tert-Butyl 4-(6-(trifluoromethyl)pyridin-3-yl)piperazine-1-carboxylate

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