Cyclamic acid

Cyclamic acid Basic information

Product Name:	Cyclamic acid
Synonyms:	cyclohexanesulphamicacid;Cyclohexylamidosulfuric acid;cyclohexylamidosulfuricacid;Cyclohexylamidosulphuric acid;cyclohexylamidosulphuricacid;Cyclohexylaminesulfonic acid;cyclohexylaminesulfonicacid;Cyclohexylaminesulphonic acid
CAS:	100-88-9
MF:	C6H13NO3S
MW:	179.24
EINECS:	202-898-1
Product Categories:	HEXAMIC ACID;Amines;Sulfur & Selenium Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds
Mol File:	100-88-9.mol

Cyclamic acid Chemical Properties

Melting point	~180 °C (dec.)
Boiling point	332.48℃[at 101 325 Pa]
density	1.149 (estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5500 (estimate)
storage temp.	Refrigerator
solubility	dioxane: soluble1g/10 mL, clear, colorless (hot)
pka	pKa 2.28(H2O t=RT c=0.056) (Uncertain)
form	solid
color	White
Water Solubility	133g/L
Merck	14,2703
BRN	2208885
LogP	-1.61 at 25℃
CAS DataBase Reference	100-88-9(CAS DataBase Reference)
NIST Chemistry Reference	N-cyclohexylsulfamic acid(100-88-9)
EPA Substance Registry System	Cyclamic acid (100-88-9)

Safety Information

Safety Statements	22-24/25
WGK Germany	2
RTECS	GV6950000
HS Code	2929909000
Hazardous Substances Data	100-88-9(Hazardous Substances Data)
Toxicity	mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01774,

MSDS Information

Provider	Language
SigmaAldrich	English

Cyclamic acid Usage And Synthesis

Chemical Properties	White Solid
Uses	A non-nutritive sweetener.
Definition	ChEBI: A member of the class of sulfamic acids that is sulfamic acid carrying an N-cyclohexyl substituent.
Brand name	Hexamic Acid (Abbott).
General Description	The N-cyclohexylsulfamic acid salts of well?known therapeutic agents were prepared.
Flammability and Explosibility	Notclassified
Safety Profile	Suspected human carcinogen producing bladder tumors. Poison by intravenous route. LWdly toxic by ingestion. When heated to decomposition it emits toxic fumes of SOx and NOx.

Cyclamic acid Preparation Products And Raw materials

Raw materials	Chlorosulfonic acid-->Cyclohexylamine-->N-CYCLOHEXYLHYDROXYLAMINE-->NITROCYCLOHEXANE-->Isocyanatocyclohexane
Preparation Products	Sodium N-cyclohexylsulfamate-->Calcium bis(cyclohexylsulphamate)

Nickel bis(sulphamidate) Hyaluronic acid Sulfanilic acid Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid Ethylbenzyl dimethylalkylammonium cyclohexylsulfamate Sulfamic acid monosodium salt 4-Amino-benzenesulfonic acid monosodium salt Ammonium sulfamate Stearic acid Folic acid 4-(Dimethylamino)-2-isopropyl-2-phenylvaleronitrile cyclamate Sulfamic acid Cyclamic acid CYCLAMIC ACID SODIUM SALT,cyclamic acid sodium crystalline,Cyclamic acid sodium CYCLAMIC ACID HEMICALCIUM SALT Molasses Citric acid

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