ChemicalBook Product Catalog Biochemical Engineering Polypeptide GLUCAGON HYDROCHLORIDE(HUMAN)

GLUCAGON HYDROCHLORIDE(HUMAN)

GLUCAGON HYDROCHLORIDE(HUMAN) Basic information
Product Name:GLUCAGON HYDROCHLORIDE(HUMAN)
Synonyms:Hyperglycemic-glycogenolytic factor;l-l-alpha-aspartyl-l-seryl-l-arginyl-l-arginyl-l-alanyl-l-glutaminyl-l-alpha-a;spartyl-l-phenylalanyl-l-valyl-l-glutaminyl-l-tryptophyl-l-leucyl-l-methionyl-;threonyl-l-seryl-l-alpha-aspartyl-l-tyrosyl-l-seryl-l-lysyl-l-tyrosyl-l-leucy;GLUCAGON HYDROCHLORIDE(HUMAN);glucagon[pig];glukagonnovo;his-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-a
CAS:9007-92-5
MF:C153H226ClN43O49S
MW:3519.21
EINECS:232-708-2
Product Categories:Amino Acids & Derivatives;Peptides
Mol File:9007-92-5.mol
GLUCAGON HYDROCHLORIDE(HUMAN) Structure
GLUCAGON HYDROCHLORIDE(HUMAN) Chemical Properties
storage temp. 2-8°C
solubility Methanol (Very Slightly, Heated, Sonicated), Water
form powder
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS LZ3980000
F 3-10-21
Hazardous Substances Data9007-92-5(Hazardous Substances Data)
MSDS Information
GLUCAGON HYDROCHLORIDE(HUMAN) Usage And Synthesis
DescriptionGlucaGon, a recombinant DNA product, was developed as a nasal formulation of glucagon for the treatment of insulin-induced hypoglycemia. Glucagon is widely used by insulin dependent diabetic patients as an emergency treatment for severe hypoglycemic reactions. Use of genetically engineered glucagon by both intranasal and intramuscular methods has a similar effect on hepatic glucose production rate as natural glucagon from pancreatic extraction.
Originator Novo-Nordisk (Denmark)
UsesGlucagon is a hormone secreted by the pancreas that raises blood glucose levels. Glucagon is released by the pancreas when blood sugar (glucose) levels fall too low. Glucagon causes the liver to convert stored glycogen into glucose thus increasing glucose levels and having the opposite effect of insulin.
Manufacturing ProcessThe process comprises treating pancreatic gland material having hyperglycemic activity in aqueous solution at pH 3-4 with 3-4 volumes of acetone to precipitate the hyperglycemic activity material, separating the precipitate and dializing the precipitate to remove inorganic salts and dialyzable low molecular weight impurities, and crystallizing the undialyzed hyperglycemic activity material from aqueous glycine buffer.
Brand nameGlucaGen
Therapeutic FunctionAntidiabetic
GLUCAGON HYDROCHLORIDE(HUMAN) Preparation Products And Raw materials
Raw materialsAcetone
GLP-1 GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN GLP-1（Glucagon-like peptide-1）(7-36) glucagon-like peptide 1 H-HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-NH2 (MET(O)27)-GLUCAGON (1-29) (HUMAN, BOVINE, PORCINE) H-MET-NH2 HCL D-ASPARTIC ACID ALPHA-AMIDE HYDROCHLORIDE H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH H-L-METHR-OH HCL L-Threonine hydrochloride H-GLY-LEU-MET-NH2 HCL H-L-MESER-OH HCL L-Tryptophanamide hydrochloride H-GLN-NH2 HCL BOMBESIN 13-14 FOR-MET-ALA-SER-OH H-ASN-NH2 HCL
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