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| | ISOXATHION Basic information |
| Product Name: | ISOXATHION | | Synonyms: | e-48;o,o-diethylo-(3-(5-phenyl)-1,2-isoxazolyl)phosphorothionate;o,o-diethylo-(5-phenyl-3-isoxazolyl)phosphorothioate;phosphorothioicacid,o,o-diethylo-(5-phenyl-3-isoxazolyl)ester;si-6711;PHOSPHOROTHIOICACID,O,O-DIETHYLO-(5-PHENYL-3-ISOXAZOLYL);ISOXATHION STANDARD;ISOXATHION | | CAS: | 18854-01-8 | | MF: | C13H16NO4PS | | MW: | 313.31 | | EINECS: | 242-624-8 | | Product Categories: | | | Mol File: | 18854-01-8.mol |  |
| | ISOXATHION Chemical Properties |
| Melting point | <25℃ | | Boiling point | 160°C (rough estimate) | | density | 1.48 g/ml | | vapor pressure | <1.3 x 10-4 Pa (25 °C) | | storage temp. | 0-6°C
| | solubility | Chloroform (Slightly), Methanol (Slightly) | | Water Solubility | 1.9 mg l-1 (25 °C) | | pka | -6.17±0.28(Predicted) | | form | liquid | | color | Colourless to Pale Yellow | | Specific Gravity | 1.48 | | BRN | 1222135 | | EPA Substance Registry System | Isoxathion (18854-01-8) |
| | ISOXATHION Usage And Synthesis |
| Description | Isoxathion is a pale yellow liquid, bp 160 ?C/0.15 mm
Hg, vp <0.133mPa (25 ?C). Solubility in water is 1.9 mg/L
(25 ?C). It is readily soluble in most organic solvents. Log
Kow = 3.88. It is unstable to alkali. | | Uses | Isoxathion is used to control sucking pests, leaf miners and some
chewing pests in a variety of fruit, vegetables and ornamental plants. | | Uses | Isoxathion is used as a pesticide. | | Definition | ChEBI: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group is replaced by a 5-phenyl-1,2-oxazol-3-yl group. | | Metabolic pathway | The principal route of isoxathion metabolism in soil, plants and mammals
is by hydrolysis, probably via the oxon to 3-hydroxy-5-phenylisoxazole
which is rapidly conjugated in both plants and rats. In soils, and to a
lesser extent in plants and mammals, further metabolism of 3-hydroxy-
5-phenylisoxazole proceeds via opening of the isoxazole ring to give
various metabolites of which benzoic acid is one of the more important.
De-ethylation of the phosphate moiety has not been observed. | | Metabolism | The principal degradation route of isoxathion in animals,
plants, and soil is cleavage of P?O-isoxazole through
oxidative desulfuration to the oxon followed by hydrolysis
to 3-hydroxy-5-phenylisoxazole, which is conjugated in
both plants and rats. | | Toxicity evaluation | The acute oral LD50 for rats is 112 mg/kg. NOEL
(2 yr) for rats is 1.2 mg/kg b.w. DT50 in soil is 9–40 d. | | Degradation | Isoxathion is unstable to alkalis (PM). The hydrolysis product, 3-hydroxy-
5-phenylisoxazole (2), yielded 5-phenyl-3H-oxazolin-2-one (3) as the
major photoproduct via a photolytic rearrangement (Nakagawa et al.,1974). |
| | ISOXATHION Preparation Products And Raw materials |
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