Flunoxaprofen

Flunoxaprofen Basic information
Product Name:Flunoxaprofen
Synonyms:Flunoxaprofen;(S)-2-(4-Fluorophenyl)-α-methyl-5-benzoxazoleacetic acid;Priaxim;S-(+)-Flunoxaprofen;Flunoxaprofen USP/EP/BP;5-Benzoxazoleacetic acid, 2-(4-fluorophenyl)-α-methyl-, (αS)-
CAS:66934-18-7
MF:C16H12FNO3
MW:285.273
EINECS:
Product Categories:
Mol File:66934-18-7.mol
Flunoxaprofen Structure
Flunoxaprofen Chemical Properties
Melting point 162-164°
alpha D20 +50° (c = 2% in DMF)
Boiling point 419.4±30.0 °C(Predicted)
density 1.334±0.06 g/cm3(Predicted)
pka4.36±0.30(Predicted)
Safety Information
ToxicityLD50 orally in mice: ~1200 mg/kg (Dunwell)
MSDS Information
Flunoxaprofen Usage And Synthesis
DescriptionFlunoxaprofen is an antiinflammatory related to now withdrawn benoxaprofen, reportedly useful in the treatment of rheumatoid arthritis, myositis, synovitis and osteoarthritis. Its major mechanism of action is reported to be lipoxygenase inhibition, thus enabling the control of inflammation with less severe gastric disturbances.
OriginatorRavizza (Italy)
DefinitionChEBI: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.
Brand namePriaxim
Flunoxaprofen Preparation Products And Raw materials
2-(4-Fluorophenyl)-α-methyl-5-benzoxazoleacetic acid Flunoxaprofen 2-(4-FLUOROPHENYL)BENZOXAZOLE 2-(4-Fluorophenyl)oxazole

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