2-Bromophenol

2-Bromophenol Basic information

Product Name:	2-Bromophenol
Synonyms:	2-BROMO-1-HYDROXYBENZENE;2-BROMOPHENOL;2- broMinephenol;Adjacent broMophenol;2-Bromfenol;2-bromo-pheno;o-bromo-pheno;Phenol, o-bromo-
CAS:	95-56-7
MF:	C6H5BrO
MW:	173.01
EINECS:	202-432-7
Product Categories:	Building Blocks;C6 to C8;Cell Biology;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Bromine Compounds;Phenols;Organic Building Blocks;Oxygen Compounds;BromoOrganic Building Blocks;PhenolsAnalytical Standards;A-BChemical Class;Alcohols;Alpha Sort;AromaticAnalytical Standards;AromaticsAlphabetic;B;BI - BZChemical Class;Chemical Class;Halogenated;PhenolsMore...Close...;Volatiles/ Semivolatiles;alcohol\| alkyl bromide;Bioactive Small Molecules
Mol File:	95-56-7.mol

2-Bromophenol Chemical Properties

Melting point	5 °C
Boiling point	195 °C(lit.)
density	1.492 g/mL at 25 °C(lit.)
refractive index	n20/D 1.589(lit.)
Fp	108 °F
storage temp.	Flammables area
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
pka	8.45(at 25℃)
color	Clear colorless to slightly yellow
Water Solubility	soluble
Sensitive	Light Sensitive
Merck	14,1428
BRN	1905115
CAS DataBase Reference	95-56-7(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 2-bromo-(95-56-7)
EPA Substance Registry System	o-Bromophenol (95-56-7)

Safety Information

Hazard Codes	Xn,F,Xi
Risk Statements	10-22-36/37/38
Safety Statements	16-36/37/39-37/39-26-36
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	SJ7875000
F	8-10-23
Hazard Note	Irritant
TSCA	Yes
HazardClass	3.2
PackingGroup	III
HS Code	29081000
Hazardous Substances Data	95-56-7(Hazardous Substances Data)

MSDS Information

Provider	Language
2-Bromophenol	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Bromophenol Usage And Synthesis

Description	2-Bromophenol is an organic substance in which the C2 position of the benzene ring is replaced by a bromine, also known as o-bromophenol.
Chemical Properties	Clear colorless to slightly yellow liquid.Soluble in chloroform and ether.
Uses	2-Bromophenol is used in organic synthesis to prepare anti-benzofurandiimideand 1-bromodibenzodioxin. It can also be used as a disinfectant.
Definition	ChEBI: 2-bromophenol is a bromophenol. It has a role as a marine metabolite.
Toxicology	2-Bromophenol is moderately acutely orally toxic to mice, and it exhibits strong irritant properties.
Synthesis	To a stirred solution of appropriate organoboronic acids (0.5 mmol, 1.0 equiv.) and Et₃N(1.0 mmol, 2.0 equiv.) in CH₃CN(acetonitrile: 3 mL, H2O: 11μL, 0.6mmol, 1.2 equiv.), DAIB (0.75 mmol, 1.5 equiv.),dissolved in acetonitrile (2mL) was added drop wise at room temperature and the mixture was allowed to stir for 10 minutes at that temperature. After completion of the reaction indicated by TLC, the reaction mixture was washed with distilled water (3×7 mL) and extracted with CH₂Cl₂(3×10 mL). The combined organic phase was dried over Na₂SO₄ and after evaporating the solvent, the residue was purified by column chromatography over silica gel using hexane/EtOAc as eluent to provide the pure target product 2-Bromophenol.

2-Bromophenol Preparation Products And Raw materials

Raw materials	Phenol, 2-bromo-, 1-benzenesulfonate-->1-broMo-2-(but-3-enyloxy)benzene-->4-BROMOPHENYL TRIFLUOROMETHANESULFONATE-->2-Bromophenylboronic acid-->1-BroMo-2-(2-propen-1-yloxy)-benzene-->4-Hydroxyphenylboronic acid pinacol ester
Preparation Products	2-ISOPROPOXYPHENYLBORONIC ACID-->2,3-Dihydrobenzo[b]furan-5-carbaldehyde-->2-Benzyloxyphenylboronic acid-->4-Bromophenol-->2-Bromoanisole-->2-Chlorophenol-->1-BROMO-2-(TERT-BUTOXY)BENZENE-->1,4-Benzodioxan-->5-BROMO-3,3-DIMETHYL-2,3-DIHYDROBENZOFURAN-->2-Bromo-6-nitrophenol

3,4,5,6-TETRABROMO-O-CRESOL 1,2,5-dimethoxy-4-bromophenol-2-aminopropane 2-(aminomethyl)-4-bromophenol 3-(aminomethyl)-4-bromophenol 4-Bromo-2,5-dimethylphenol 2-Nitro-5-bromophenol 4,4'-Sulphonylbis(2,6-dibromophenol) 2-(1H-BENZIMIDAZOL-2-YL)-4-BROMOPHENOL 4-Bromo-2,6-dimethylphenol PHENOLDISULFONIC ACID bromophenol 2-Bromophenol, ethyl ether 2-Amino-4-bromophenol hydrochloride 3-BROMO-2-CHLOROPHENOL 2-Borono-4-bromophenol 4-chloro-2-bromophenol 2-[(1H-1,2,3-benzotriazol-5-ylimino)methyl]-4-bromophenol 2-(1-ADAMANTYL)-4-BROMOPHENOL,2-(Adamantan-1-yl)-4-bromophenol 98%,2-(1-Adamantyl)-4-bromophenol (Adapalene)

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