|
| | RUGULOSIN Basic information |
| Product Name: | RUGULOSIN | | Synonyms: | (+)-RUGULOSIN;RUGULOSIN;(+)-(1S,1'S,2R,2'R,3S,3'S,9AR,9'AR)-RUGULOSIN;(+)-Rugulosin, (1S,1S,2R,2R,3S,3S,9aR,9aR)-Rugulosin, (2R,2R)-Rugulosin;5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-;5H,6H-6,13A,5A,14-[1,2,3,4]Butanetetraylcycloocta[1,2-B:5,6-B']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-, [5as-(5ar*,6S*,13ar*,14S*,17R*,18S*,19S*,20R*)]-;Nsc160880;NSC 249990 | | CAS: | 23537-16-8 | | MF: | C30H22O10 | | MW: | 542.49 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 23537-16-8.mol |  |
| | RUGULOSIN Chemical Properties |
| Melting point | 293℃ (decomposition) | | Boiling point | 535.95°C (rough estimate) | | density | 1.3164 (rough estimate) | | refractive index | 1.5376 (estimate) | | storage temp. | Store at -20°C | | solubility | DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | form | A solid | | pka | 4.20±1.00(Predicted) | | IARC | 3 (Vol. 40, Sup 7) 1987 | | EPA Substance Registry System | 5H,6H-6,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-, (5aS,6R,13aS,14R,17S,18R,19R,20S)- (23537-16-8) |
| | RUGULOSIN Usage And Synthesis |
| Description | (+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 μM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 μM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 μM. (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet. It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 μg/ml, respectively). | | Uses | Rugulosin (+ form) is an intense yellow pigment produced by Penicillium and Aspergillus. | | Uses | (+)-Rugulosin is an intense yellow pigment produced by some species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. (+)-Rugulosin shows antibacterial and insecticidal activity and has found application as a bioinsecticide, notably as the active secondary metabolite in endophytic fungi of seedlings. | | Definition | ChEBI: Rugulosin is a cyclic ketone and an organic polycyclic compound. |
| | RUGULOSIN Preparation Products And Raw materials |
|
