2-Chloro-4-cyanopyridine

2-Chloro-4-cyanopyridine Basic information

Product Name:	2-Chloro-4-cyanopyridine
Synonyms:	6-Chloro-4-cyanopyridine;2-Chloro-4-pyridinecarbonitrile,2-Chloro-4-cyanopyridine;2-Chloro-4-cyanopyri;2-Chloroisonicotinonitrile 2-Chloro-4-pyridinecarbonitrile;2-Chloro-4-cyanopyridine, 2-Chloropyridine-4-carbonitrile;2-4 - cyanopyridine chloride -;2-Chloro-4-cyanopyridine,97%;4-Pyridinecarbonitrile, 2-chloro-
CAS:	33252-30-1
MF:	C6H3ClN2
MW:	138.55
EINECS:	608-852-0
Product Categories:	Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridine;Chloropyridines;Halopyridines;blocks;Carboxes;Pyridines;Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;bc0001
Mol File:	33252-30-1.mol

2-Chloro-4-cyanopyridine Chemical Properties

Melting point	69-73 °C(lit.)
Boiling point	104-106°C 15mm
density	1.33±0.1 g/cm3(Predicted)
Fp	104-106°C/15mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-1.60±0.10(Predicted)
form	powder to crystal
color	White to Almost white
BRN	113927
InChIKey	QRXBTPFMCTXCRD-UHFFFAOYSA-N
CAS DataBase Reference	33252-30-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-36-36/37/39-36/37
RIDADR	3276
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

2-Chloro-4-cyanopyridine Usage And Synthesis

Chemical Properties	White to off-white solid
Uses	2-Chloro-4-cyanopyridine is an intermediate used to prepare pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). It is also used to synthesize pyridinyl-tetrazoles as scaffold to identify matrix MMP-13 inhibitors for treatment of osteoarthritis.

2-Chloro-4-cyanopyridine Preparation Products And Raw materials

Raw materials	2-Chloro-4-nitropyridine 1-oxide
Preparation Products	1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE-->2-Methoxy-4-pyridinecarboxylic acid-->2-PHENYL-ISONICOTINIC ACID-->4-CYANO-2-METHOXYPYRIDINE-->RG120-->N-(4-CYANO-2-PYRIDINYL)-ACETAMIDE-->2-(dimethylamino)isonicotinonitrile-->N-benzyl-2-chloropyridine-4-carboxamide-->2-CHLORO-N-HYDROXY-ISONICOTINAMIDINE-->2-(phenylaMino)isonicotinonitrile

3-AMINO-2,6-DICHLORO-4-CYANOPYRIDINE 2-CHLORO-6-(4-METHYLPHENOXY)ISONICOTINONITRILE 2-CHLORO-6-(4-CHLOROPHENOXY)ISONICOTINONITRILE 2-CHLORO-6-(PHENYLTHIO)ISONICOTINONITRILE 2-CHLORO-6-(3,5-DICHLOROPHENOXY)ISONICOTINONITRILE CYANOPYRIDINE 2,3,5,6-TETRACHLOROISONICOTINONITRILE MCPA SOLUTION 100 NG/MYL IN ACETONITRIL& 2-CHLORO-6-[(5-HYDROXY-4-PHENYL-4H-1,2,4-TRIAZOL-3-YL)THIO]ISONICOTINONITRILE 2,6-Dichloroisonicotinonitrile 2-CHLORO-4-CYANOQUINOLINE MCPA SODIUM 2,3,5-TRICHLORO-6-PIPERAZIN-1-YLISONICOTINONITRILE 2-CHLORO-4-CYANOPYRIDINE-N-OXIDE 2-(4-BROMOPHENOXY)-6-CHLOROISONICOTINONITRILE 2-CHLORO-6-(2-PYRIDYLTHIO)ISONICOTINONITRILE 2,3,5-TRICHLORO-6-(1,4-DIAZEPAN-1-YL)ISONICOTINONITRILE Cyano

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