N-Methyl-N-nitrosotoluene-4-sulphonamide

N-Methyl-N-nitrosotoluene-4-sulphonamide Basic information

Product Name:	N-Methyl-N-nitrosotoluene-4-sulphonamide
Synonyms:	Benzenesulfonamide, N,4-dimethyl-N-nitroso-;Benzenesulfonamide,N,4-dimethyl-N-nitroso-;Diazale;diazalo;Methylnitroso-p-toluenesulfonamide;n,4-dimethyl-n-nitroso-benzenesulfonamid;P-TOLUENESULFONYL-N-METHYL-N-NITROSAMIDE;P-TOLUENESULFONYL-N-METHYL-N-NITROSOAMIDE
CAS:	80-11-5
MF:	C8H10N2O3S
MW:	214.24
EINECS:	201-252-6
Product Categories:	Amines;Aromatics;Pharmaceutical Intermediates;Sulfur & Selenium Compounds
Mol File:	80-11-5.mol

N-Methyl-N-nitrosotoluene-4-sulphonamide Chemical Properties

Melting point	~58 °C
Boiling point	320.5±35.0 °C(Predicted)
density	1.3844 (rough estimate)
refractive index	1.5690 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Dichloromethane (Sparingly), DMSO (Slightly), Ethyl Acetate
pka	-19.25±0.70(Predicted)
form	Solid
color	Pale Yellow to Yellow
Merck	13,9621
Stability:	Stable, but heat sensitive; may also be light sensitive. Incompatible with strong oxidizing agents, alkalies.
CAS DataBase Reference	80-11-5(CAS DataBase Reference)
NIST Chemistry Reference	N-methyl-n-nitroso, p-toluene sulfonamide(80-11-5)
EPA Substance Registry System	Benzenesulfonamide, N,4-dimethyl-N-nitroso- (80-11-5)

Safety Information

MSDS Information

Provider	Language
Diazald	English
SigmaAldrich	English

N-Methyl-N-nitrosotoluene-4-sulphonamide Usage And Synthesis

Chemical Properties	pale yellow crystalline powder
Uses	N-Methyl-N-nitroso-p-toluenesulfonamide is Diazomethane precursor.
Uses	In the laboratory preparation of diazomethane. Directions for use: de Boer, Backer, Rec. Trav. Chim. 73, 232 (1954).
Definition	ChEBI: N,4-dimethyl-N-nitrosobenzenesulfonamide is a sulfonamide.
Purification Methods	Crystallise diazald from *benzene by addition of pet ether and store it in a refrigerator. It is soluble in most organic solvents and liberates diazomethane on treatment with alkali. Store it in the cold. [deBoer & Backer Org Synth 34 96 1954, Beilstein 11 I 29.]

N-Methyl-N-nitrosotoluene-4-sulphonamide Preparation Products And Raw materials

Raw materials	Tosyl chloride-->Benzenesulfonicacid, 4-methyl-, 1-methylhydrazide-->(Z)-POTASSIUMMETHANEDIAZOTATE-->Nitrous acid, cyclopentyl ester-->Methylamine-->N-Methyl-p-toluenesulfonamide
Preparation Products	methyl 2-(7-hydroxybenzofuran-3-yl)acetate-->7-METHOXY-3(2H)-BENZOFURANONE-->N-NITROSO-DI-ISO-PROPYLAMINE-->tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate-->1-(4-bromophenyl)-2-chloroethan-1-one-->3,4-Dimethoxy-3-cyclobutene-1,2-dione-->BICYCLO[3.3.2]DECAN-9-ONE-->methyl 2-amino-4,6-dimethoxybenzoate

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