CYCLOHEXYL ISOCYANIDE

CYCLOHEXYL ISOCYANIDE Basic information
Product Name:CYCLOHEXYL ISOCYANIDE
Synonyms:Cyclohexane, isocyano-;Cyclohexaneisonitrile;BIO-FARMA BF001328;ISOCYANOCYCLOHEXANE;HANSA ISN-0519;CYCLOHEXYL ISOCYANIDE;CYCLOHEXYL ISONITRILE;Cyclohexyl #niso-cyanide
CAS:931-53-3
MF:C7H11N
MW:109.17
EINECS:213-238-7
Product Categories:ISONITRITE
Mol File:931-53-3.mol
CYCLOHEXYL ISOCYANIDE Structure
CYCLOHEXYL ISOCYANIDE Chemical Properties
Melting point 6.45°C
Boiling point 173-176 °C
density 0.878 g/mL at 25 °C(lit.)
refractive index n20/D 1.45(lit.)
Fp 170 °F
storage temp. Store at +2°C to +8°C.
form Liquid
color Clear colorless to slightly brown
BRN 3662332
Stability:Stable. Incompatible with strong acids, strong bases, strong reducing agents, strong oxidizing agents. Flammable.
CAS DataBase Reference931-53-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,T
Risk Statements 20/21/22-23/24/25
Safety Statements 36/37-45-24/25
RIDADR UN 2810 6.1/PG 2
WGK Germany 3
10-13-21
HazardClass 6.1
PackingGroup III
HS Code 29299090
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
CYCLOHEXYL ISOCYANIDE Usage And Synthesis
Chemical Propertiescolourless liquid
UsesCyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.
PreparationCAUTION: Use a well-ventilated hood and take all precautions before using phosgene.
To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).
Preparation of Cyclohexyl Isonitrile

DefinitionChEBI: Cyclohexyl isocyanide is an isocyanide having a cyclohexyl group attached to nitrogen. It is a conjugate base of a cyclohexyl isocyanide(1+).
General DescriptionCyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.
CYCLOHEXYL ISOCYANIDE Preparation Products And Raw materials
Preparation ProductsN,N'-DICYCLOHEXYLUREA-->N-Methylcyclohexylamine
Benzyl isocyanate Dimedone Benzyl chloride Benzeneacetonitrile Benzyl isocyanide Cyclohexanecarboxylic acid, 1-isocyano-, methyl ester (9CI) 2-(1'-ISOCYANOCYCLOHEXYL) ACETIC ACID METHYL ESTER 1,2-DIISOCYANOCYCLOHEXANE CIS-ETHYL-2-ISOCYANOCYCLO-HEXYLCARBOXYLATE 1-ADAMANTANEISOCYANIDE BIO-FARMA BF001930 Cyclohexane, 1,4-diisocyano- (9CI) ETHYL 1-ISOCYANOCYCLOHEXANECARBOXYLATE 2-METHYLCYCLOHEXYL ISOCYANIDE TRANS-ETHYL-2-ISOCYANO-CYCLOHEXYLCARBOXYLATE CYCLOHEXYL ISOCYANIDE (S,S)-1,2-DIISOCYANOCYCLO-HEXANE 4-(N-T-BUTOXYCARBONYLAMINO)CYCLOHEXYLISOCYANIDE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.