ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 4'-Hydroxy-3'-methylacetophenone

4'-Hydroxy-3'-methylacetophenone

4'-Hydroxy-3'-methylacetophenone Basic information
Product Name:4'-Hydroxy-3'-methylacetophenone
Synonyms:Ethanone, 1-(4-hydroxy-3-methylphenyl)-;1-(4-HYDROXY-3-METHYLPHENYL)ETHAN-1-ONE;1-(4-HYDROXY-3-METHYLPHENYL)ETHANONE;4-ACETYL-2-METHYLPHENOL;4'-HYDROXY-3'-METHYLACETOPHENONE;4-HYDROXY-3-METHYLACETOPHENONE;3'-Methyl-4'-Hydroxy Acetophenone;4-hydroxy-3-methylphenyl methyl ketone
CAS:876-02-8
MF:C9H10O2
MW:150.17
EINECS:212-880-5
Product Categories:Building Blocks;Carbonyl Compounds;Aromatic Acetophenones & Derivatives (substituted);Benzene series;Chemical Synthesis;Organic Building Blocks;Benzene derivatives;C9;Carbonyl Compounds;Ketones
Mol File:876-02-8.mol
4'-Hydroxy-3'-methylacetophenone Structure
4'-Hydroxy-3'-methylacetophenone Chemical Properties
Melting point 107-109 °C(lit.)
Boiling point 175°C 1mm
density 1.0858 (rough estimate)
refractive index 1.5180 (estimate)
Fp 175°C/1mm
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka8.52±0.18(Predicted)
form Solid
color Off-White to Pale Beige
BRN 2041839
Stability:Hygroscopic
LogP1.395 (est)
CAS DataBase Reference876-02-8(CAS DataBase Reference)
NIST Chemistry Reference4-Hydroxy-3-methylacetophenone(876-02-8)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 36/37/39-26-22-37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29143990
MSDS Information
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4'-Hydroxy-3'-methylacetophenone English
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ACROS English
ALFA English
4'-Hydroxy-3'-methylacetophenone Usage And Synthesis
Chemical Propertieswhite to light beige crystalline powder or
Uses4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100).
DefinitionChEBI: 4-hydroxy-3-methylacetophenone is a monohydroxyacetophenone that is acetophenone carrying methyl and hydroxy groups at positions 3 and 4, respectively. It has a role as a volatile oil component and an insect attractant. It is a monohydroxyacetophenone, a member of phenols and a hydroxytoluene. It is functionally related to an acetophenone.
PreparationPreparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%).
Synthesis Reference(s)Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008
4'-Hydroxy-3'-methylacetophenone Preparation Products And Raw materials
Raw materialsChlorine-->Dichloroacetyl chloride-->NSC 46633-->O-TOLYL ACETATE-->Acetyl chloride-->o-Cresol-->Acetic acid
Preparation ProductsChlorpyrifos-->Chlorpyrifos,E.C.-->1-(4-ethoxy-3-methylphenyl)ethanone
3'-Hydroxyacetophenone 3'-Methylacetophenone 2,4-Dihydroxyacetophenone 3-Nitroacetophenone 4-Nitroacetophenone 3,5-Dihydroxyacetophenone Acetophenone 4'-Methylacetophenone 2',4'-Dichloroacetophenone 2-HYDROXYACETOPHENONE 3'-(Trifluoromethyl)acetophenone 2'-Hydroxyacetophenone CHLOROPHOSPHONAZO III 3-Methoxyacetophenone 2'-Methylacetophenone PIPERACETAZINE (250 MG) 2',6'-Dihydroxyacetophenone 4'-(Trifluoromethyl)acetophenone
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