4-Nitrobenzyl chloroformate

4-Nitrobenzyl chloroformate Basic information

Product Name:	4-Nitrobenzyl chloroformate
Synonyms:	P-NITROBENZYL CHLOROFORMATE;P-NITROCARBOBENZOXY CHLORIDE;PNBCF;PARA-NITROBENZYL CHLOROFORMATE;4-Nitrobenzyl chloridocarbonate;4-Nitrobenzyloxycarbonyl chloride;carbonochloridicacid,(4-nitrophenyl)methylester;Chloroformic acid p-nitrobenzyl ester
CAS:	4457-32-3
MF:	C8H6ClNO4
MW:	215.59
EINECS:	224-708-6
Product Categories:	Active Esters/Additives;Active Esters/AdditivesSynthetic Reagents;Coupling;Peptide Synthesis;Benzene derivatives
Mol File:	4457-32-3.mol

4-Nitrobenzyl chloroformate Chemical Properties

Melting point	32-34 °C(lit.)
Boiling point	230°C 10mm
density	1.4928 (rough estimate)
refractive index	1.552-1.556
Fp	>230 °F
storage temp.	2-8°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly)
form	powder to crystal
color	White to Light yellow
Sensitive	Moisture Sensitive
BRN	912446
Stability:	Stable, but moisture-sensitive. May develop pressure in storage. Incompatible with moisture, strong bases, alcohols, amines, acids.
CAS DataBase Reference	4457-32-3(CAS DataBase Reference)
NIST Chemistry Reference	Carbonochloridic acid, (4-nitrophenyl)methyl ester(4457-32-3)
EPA Substance Registry System	Carbonochloridic acid, (4-nitrophenyl)methyl ester (4457-32-3)

Safety Information

Hazard Codes	C,T
Risk Statements	34-37-23/24/25-36/37
Safety Statements	26-36/37/39-45-38-28A-27
RIDADR	UN 3261 8/PG 2
WGK Germany	3
F	3-4.9
Hazard Note	Corrosive/Toxic/Moisture Sensitive
HazardClass	8
PackingGroup	III
HS Code	29159000

MSDS Information

Provider	Language
4-Nitrobenzyl chloroformate	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Nitrobenzyl chloroformate Usage And Synthesis

Chemical Properties	off-white to pale yellow powder
Uses	4-Nitrobenzyl Chloroformate is used in the preparation of prodrugs of cytotoxic acridines used in conjunction with enzyme prodrugs which counter carcinoma cells.

4-Nitrobenzyl chloroformate Preparation Products And Raw materials

Raw materials	4-Nitrobenzyl alcohol
Preparation Products	(R)-(+)-1-Boc-3-aminopyrrolidine-->3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid-->TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE-->(3R)-3-Hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Artinite ChloroMethyl Methyl Carbonate Benzyl chloroformate Nitrobenzyl alcohol Malonyl ester Benzylchloromethyl ether 4-Nitrobenzyl alcohol Chloromethyl methyl ether 4,5-DIMETHOXY-2-NITROBENZYL CHLOROFORMATE 4-(METHOXYMETHYL)ANILINE Carbobenzoxyhydrazide Ethyl chloroformate Chloromethyl ethyl ether Methyl chloroformate 4-Nitrobenzyl chloroformate Benzyl formate Chloroformate Benzyl benzoate 4-Methylaniline hydrochloride

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