4-Fluoro-3-nitrobenzoic acid

4-Fluoro-3-nitrobenzoic acid Basic information

Product Name:	4-Fluoro-3-nitrobenzoic acid
Synonyms:	4-Carboxy-2-nitrofluorobenzene;5-Carboxy-2-fluoronitrobenzene;4-Fluoro-3-nitrobenzoic acid, 98% 5GR;4-Fluoro-3-nitrobenzoic acid,98%;NSC 10311;4-Fluoro-3-nitrobenzoic Acid, 97+%;Benzoic acid, 4-fluoro-3-nitro-;p-Fluoro-3-nitrobenzoic acid
CAS:	453-71-4
MF:	C7H4FNO4
MW:	185.11
EINECS:	207-221-3
Product Categories:	Benzenes;C7Fluorescent Probes, Labels, Particles and Stains;Carbonyl Compounds;Carboxylic Acids;Fluorescent Labels;Other Fluorescent Labels;Fluorobenzoic acids;Benzoic acid;Miscellaneous;Other Fluorescent Labels;Aryl Fluorinated Building Blocks;Biochemicals and Reagents;Building Blocks;C7;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Fluorescent Labels;Fluorescent Probes;Fluorinated Building Blocks;Benzoic acid series;Aromatics;Miscellaneous Reagents;blocks;Carboxes;FluoroCompounds;NitroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Labels;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Particles and Stains
Mol File:	453-71-4.mol

4-Fluoro-3-nitrobenzoic acid Chemical Properties

Melting point	123-126 °C (lit.)
Boiling point	92°C 15mm
density	1.5071 (estimate)
Fp	92°C/15mm
storage temp.	Sealed in dry,Room Temperature
solubility	95% ethanol: soluble50mg/mL, clear, light yellow
pka	3.54±0.10(Predicted)
form	Powder or Crystals
color	Light yellow to tan
Water Solubility	insoluble
BRN	2107562
CAS DataBase Reference	453-71-4(CAS DataBase Reference)
NIST Chemistry Reference	4-Fluoro-3-nitrobenzoic acid(453-71-4)

Safety Information

MSDS Information

4-Fluoro-3-nitrobenzoic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluoro-3-nitrobenzoic acid was used:

as starting reagent in the preparation of novel benzimidazoles having antimycobacterial activity
in preparation of series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure
in preparation of bis(heterocyclic) skeletal precursors for the Pictet-Spengler reaction
in solid-phase synthesis of trisubstituted [1,3,5]triazino[1,2-a]benzimidazole-2,4(3H,10H)-diones

4-Fluoro-3-nitrobenzoic acid Preparation Products And Raw materials

Raw materials	4-FLUORO-3-NITROBENZONITRILE-->3-NITRO-4-FLUOROBENZOYL CHLORIDE-->4-Fluoro-3-nitrotoluene-->Azidotrimethylsilane-->4-Fluoronitrobenzene-->4-Fluorobenzaldehyde-->Isopropyl alcohol-->4-Fluorobenzoic acid-->p-Fluorotoluene-->Nitric acid
Preparation Products	ETHYL 3-AMINO-4-(METHYLAMINO)BENZOATE-->4-(cyclohexylamino)-3-nitro-benzoic acid ethyl ester-->4-(2-METHOXY-ETHYLAMINO)-3-NITRO-BENZOIC ACID-->4-CYCLOHEXYLAMINO-3-NITRO-BENZOIC ACID-->3-Amino-4-(methylamino)benzamide

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