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| | FENAMIDONE Basic information |
| Product Name: | FENAMIDONE | | Synonyms: | (S)-4-Methyl-2-(methylthio)-4-phenyl-1-(phenylamino)-1H-imidazol-5(4H)-one;Fenamidone 100mg [161326-34-7];Fenamidone-[13C6];FENOMEN;FENAMIDONE;(5S)-3-anilino-5-methyl-2-methylsulfanyl-5-phenylimidazol-4-one;REASON;(S)-1-ANILINO-4-METHYL-2-METHYLTHIO-4-PHENYL-2-IMIDAZOLIN-5-ONE | | CAS: | 161326-34-7 | | MF: | C17H17N3OS | | MW: | 311.4 | | EINECS: | | | Product Categories: | | | Mol File: | 161326-34-7.mol |  |
| | FENAMIDONE Chemical Properties |
| Melting point | 137° | | Boiling point | 443.0±48.0 °C(Predicted) | | density | 1.285 | | storage temp. | 0-6°C | | pka | 0.49±0.40(Predicted) | | form | neat | | LogP | 3.610 (est) | | EPA Substance Registry System | Fenamidone (161326-34-7) |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 60-61 | | RIDADR | UN3077 9/PG 3 | | WGK Germany | 2 | | Toxicity | LD50 in male, female rats (mg/kg): >5000, 2028 orally; in rats (mg/kg): >2000 dermally; LC50 in bobwhite quail, mallard duck (mg/kg): >5200, >5200 dietary (Mercer) |
| | FENAMIDONE Usage And Synthesis |
| Description | Fenamidone (13; RPA 407213; (S)-5-methyl-2-methylthio-
5-phenyl-3-phenylamino-3,4-dihydroimidazol-4-one) is a complex III inhibitor
that does not derive from the strobilurins but rather
belongs to the imidazolinone chemical class. Fenamidone is a white woolly powder, with the
following characteristics: mp = 137 ?C; water solubility =
7.8 mg/L; logP = 2.8, and vp = 3.4×10?7 Pa. It was
first described by Mercer et al. (39) in 1998. Only the
S-enantiomer shows antifungal activity, thus offering a
reduction in application rates over the racemic mixture. | | Uses | Fungicide. | | Definition | ChEBI: A member of the class of imidazolones that is 3,5-dihydroimidazol-4-one substituted at position 2 by a methylthiogroup, at position 3 by an anilino group and at position 5 by phenyl and methyl groups (the S-enantiomer). A fungicide effecti
e against Oomycete diseases such as downy mildew and certain leaf spot diseases. | | Hazard | Moderately toxic by ingestion and skin contact. Low toxicity by inhalation. | | Toxicity evaluation | Fenamidone has an acute oral LD50 > 5,000 and an
acute dermal LD50 > 2,000 mg/kg in rats. Fenamidone is
not a skin or eye irritant, is negative in the Ames test, and
is nonteratogenic. It shows low toxicity to birds in acute
and dietary studies but has a 96-h fish LC50 of 0.74 mg/L. |
| | FENAMIDONE Preparation Products And Raw materials |
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