L-LEUCIC ACID

L-LEUCIC ACID Basic information

Product Name:	L-LEUCIC ACID
Synonyms:	(S)-2-HYDROXY-4-METHYLVALERIC ACID;L-2-hydroxy-4-methylvaleric acid;L-LEUCIC ACID;L-ALPHA-HYDROXYISOCAPROIC ACID;(S)-(-)-2 HYDROXYSOCAPROIC ACID,98%;Pentanoic acid, 2-hydroxy-4-methyl-, (2S)-;(2S)-2-hydroxy-4-methylpentanoic acid;S-2-Hydroxy-4-methylpentanoic acid
CAS:	13748-90-8
MF:	C6H12O3
MW:	132.16
EINECS:	237-329-6
Product Categories:	API intermediates;Carboxylic Acids (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;chiral
Mol File:	13748-90-8.mol

L-LEUCIC ACID Chemical Properties

Melting point	78-80 °C(lit.)
Boiling point	277.83°C (rough estimate)
density	1.0160 (rough estimate)
refractive index	-26 ° (C=2, 1 %NaOH)
storage temp.	Sealed in dry,Room Temperature
solubility	Aqueous Base (Slightly), DMSO (Sparingly), Water (Slightly)
form	Solid
pka	3.86±0.21(Predicted)
color	White to Off-White
optical activity	[α]22/D 26.3°, c = 1 in 1 M NaOH
Water Solubility	almost transparency
LogP	0.710
CAS DataBase Reference	13748-90-8(CAS DataBase Reference)
EPA Substance Registry System	Pentanoic acid, 2-hydroxy-4-methyl-, (2S)- (13748-90-8)

Safety Information

Safety Statements	24/25
WGK Germany	3
HS Code	29181990

MSDS Information

Provider	Language
SigmaAldrich	English

L-LEUCIC ACID Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.
Definition	ChEBI: The (S)-enantiomer of 2-hydroxy-4-methylpentanoic acid. Derived from the metabolism of the branched-chain amino acids, it belongs to the 2-hydroxycarboxylic acid group of amino acid metabolites.

L-LEUCIC ACID Preparation Products And Raw materials

Raw materials	Pentanoic acid, 2-bromo-4-methyl-, ethyl ester, (S)- (9CI)-->4-Methyl-2-oxovaleric acid-->L-Tyrosine-->β-Alanine-->L-Leucine-->Isovaleraldehyde
Preparation Products	(R)-2-HYDROXY-4-METHYLPENTANOIC ACID-->R-b-aminoisobutyric acid

Brovincamine [S,(-)]-3-Hydroxy-4-methylvaleric acid hydrazide [S,(-)]-2-Hydroxy-4-methylvaleric acid sodium salt,[R,(+)]-2-Hydroxy-4-methylvaleric acid sodium salt CALODENDROLIDE 1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,20-BETA-TRIOL-3-ONE 21-CARBOXYLIC ACID METHYL ESTER RUTAEVIN 4-hydroxy-2,2,6,6-tetramethylpiperidine-4-carboxylic acid 3-Hydroxy-3-methylvaleric acid sodium salt (S)-2-Hydroxy-4-methylvaleric acid methyl ester,[S,(-)]-2-Hydroxy-4-methylvaleric acid methyl ester [R,(+)]-3-Hydroxy-4-methylvaleric acid hydrazide [R,(-)]-2-Hydroxy-4-methylvaleric acid ethyl ester DEACETYLNOMILIN [R,(+)]-3-Hydroxy-4-methylvaleric acid p-bromophenacyl ester L-LEUCIC ACID Nomilin Formyl-leurosine [S,(-)]-3-Hydroxy-4-methylvaleric acid Limonin

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