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| | Dorzolamide Hydrochloride Basic information |
| Product Name: | Dorzolamide Hydrochloride | | Synonyms: | 3-b)thiopyran-2-sulfonamide,5,6-dihydro-4-(ethylamino)-6-methyl-4h-thieno(;mk-0507;monohydrochloride,(4s-trans)-7-dioxide;Dorzolomide hydrochloride, >=99%;4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride;MK-507 (L-671152) HCl;4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride (1:1), (4S,6S)-;(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxid | | CAS: | 130693-82-2 | | MF: | C10H17ClN2O4S3 | | MW: | 360.9 | | EINECS: | 620-304-2 | | Product Categories: | Inhibitors;Heterocycles;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Dorzolamide;API;Trusopt, Cosopt;Other APIs | | Mol File: | 130693-82-2.mol |  |
| | Dorzolamide Hydrochloride Chemical Properties |
| Melting point | 265-2670C | | alpha | D24 -8.34° (c = 1 in methanol) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol. | | form | neat | | color | White to Off-White | | λmax | 254nm(CHCl3:MeOH= aq.)(lit.) | | Merck | 14,3426 | | BRN | 5896026 | | CAS DataBase Reference | 130693-82-2(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | XJ9095163 | | HS Code | 2935904000 |
| | Dorzolamide Hydrochloride Usage And Synthesis |
| Description | Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops
for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a
potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular
pressure (IOP). In a clinical study in patients with bilateral primary open-angle
glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower
IOP throughout the day. Dorzolamide has been shown to be effective as a single
therapy or in combination with β-blockers. | | Description | Dorzolamide (hydrochloride) (Item No. 26303) is an analytical reference standard categorized as a carbonic anhydrase inhibitor diuretic. Diuretics have been used in sports doping to reduce weight or anabolic androgenic steroid-induced water retention, or as masking agents. This product is intended for use in analytical forensic applications. This product is also available as a general research tool . | | Chemical Properties | White Powder | | Originator | Merck (U.S.A.) | | Uses | Carbonic anhydrase inhibitor. Antiglaucoma agent. | | Uses | Antiglaucoma drug;Carbonic anhydrase inhibitor | | Uses | analgesic | | Uses | Dorzolamide HCl Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. | | Uses | An inhibitor of carbonic anhydrase. | | Definition | ChEBI: The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. | | Manufacturing Process | Manufacturing process for Dorzolamide hydrochloride includes these steps as follows: Step A: Sulfuric Acid Ritter Procedure;Step B: Sulfonylation Procedure Step C: Chlorosulfonylation Procedure;Step D: Amidation Procedure;Step E: Reduction via Borane Generated in situ Procedure;Step F: Maleate Salt Formation Procedure;Step G: Crude Hydrochloride Salt Formation;Step H: Recrystallization Procedure. | | Brand name | Trusopt (Merck). | | Therapeutic Function | Antiglaucoma | | Veterinary Drugs and Treatments | Dorzolamide is often used in the contralateral eye of a dog with
primary glaucoma to prevent development of bilateral disease. It
is also an excellent agent to consider for most secondary glaucomas
in dogs and cats because it has no effect on pupil size. Like the
related oral carbonic anhydrase inhibitors (dichlorphenamide or
Daranide?, methazolamide or Neptazane?), dorzolamide decreases
aqueous humor production by the ciliary body epithelium by altering
pH and affecting the H+/Na+ active transport exchange mechanism.
Oral carbonic anhydrase inhibitors cause numerous systemic
side effects such as metabolic acidosis and panting, diarrhea, vomiting,
anorexia and others, all of which can be avoided with topical
carbonic anhydrase inhibitors. |
| | Dorzolamide Hydrochloride Preparation Products And Raw materials |
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