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| | GNE-9605 Basic information |
| Product Name: | GNE-9605 | | Synonyms: | GNE-9605;N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;Diazepam-d8 (exempt preparation);CS-1831;GNE-9605;GNE9605;GNE 9605;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-;GNE-9605 USP/EP/BP | | CAS: | 1536200-31-3 | | MF: | C17H20ClF4N7O | | MW: | 449.83 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1536200-31-3.mol |  |
| | GNE-9605 Chemical Properties |
| Boiling point | 587.9±60.0 °C(Predicted) | | density | 1.67±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | ≥22.5 mg/mL in DMSO | | form | solid | | pka | 5.04±0.60(Predicted) |
| | GNE-9605 Usage And Synthesis |
| Description | GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease. | | references | [1]. estrada aa, chan bk, baker-glenn c, et al. discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (lrrk2) small molecule inhibitors. j med chem, 2014, 57(3): 921-936. |
| | GNE-9605 Preparation Products And Raw materials |
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