LY2886721

LY2886721 Basic information
Uses
Product Name:LY2886721
Synonyms:LY2886721;N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide;LY2886721 HCL SALT;LY2886721HCL;N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide LY2886721;LY2886721, >=98%;N-(3-((4aS,7aS)-2-aMino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinaMide;LY2886721/LY-2886721
CAS:1262036-50-9
MF:C18H16F2N4O2S
MW:390.41
EINECS:
Product Categories:Inhibitors
Mol File:1262036-50-9.mol
LY2886721 Structure
LY2886721 Chemical Properties
density 1.57
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.52 mg/mL in DMSO
form solid
pka10.08±0.70(Predicted)
Safety Information
MSDS Information
LY2886721 Usage And Synthesis
UsesLY2886721 is a BACE inhibitor used to treat Alzheimer's disease.
Biological Activityly2886721 is an oral and furothiazine-based inhibitor of β site-amyloid protein cleaving enzyme (bace) with ic50 of 20.3nm. this product has the potency for the treatment of alzheimer's disease.bace, also known as beta-secretase 1, is an aspartic-acid protease that plays important role in the formation of myelin sheaths in peripheral nerve cells.in pdapp mice, oral administration of ly2886721 resulted in a reduction in brain aβ, c99 and sappβ in a dose-dependent pattern 2. aβ levels in the brain were decreased by 20% -65% as compared with the vehicle-treated groups 3 hours after treatment of ly2886721 at a dosage of 3-30 mg/kg per mice. in addition, ly2886721 significantly lowers plasma and csf aβs in the mad study 1.
in vitrotreatment of ly2886721 leads to the inhibition of aβ in hek293swe with ic50 of 18.7nm and pdapp neuronal culture with ic50 10.7 nm1. ly2886721 decreases csf sappβ and increases csf sappα in a dose- dependent manner 2.
targetBACE
references1. vassar r. bace1 inhibitor drugs in
LY 2157299 Rapamycin LY 294002 HYDROCHLORIDE LY2811376 LY-2608204 LY 2874455 LY2090314 LY 310762 LY411575 LY-364947 LY2409881 trihydrochloride Gemcitabine LY-2584702 (tosylate salt) Saracatinib Sulfanilamide Tilmicosin Abemaciclib Selumetinib

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