ChemicalBook Product Catalog Natural Products Alkaloids BANISTERINE MONOHYDRATE

BANISTERINE MONOHYDRATE

BANISTERINE MONOHYDRATE Basic information
Product Name:BANISTERINE MONOHYDRATE
Synonyms:Harmine;1-Methyl-7-Methoxy-β-carboline;Hal base;Harmine(Banisterine);1-Methyl-7-methoxy-beta-carboline;4-b)indole,7-methoxy-1-methyl-9h-pyrido(;7-Methoxy-1-methyl-9H-beta-carboline;9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-
CAS:442-51-3
MF:C13H12N2O
MW:212.25
EINECS:207-131-4
Product Categories:reagent;standard substance;Inhibitors;Signalling;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorescent;Heterocyclic;Heterocyclic Compounds;Alkaloids;Biochemistry;Indole Alkaloids;Neurochemicals
Mol File:442-51-3.mol
BANISTERINE MONOHYDRATE Structure
BANISTERINE MONOHYDRATE Chemical Properties
Melting point 262-264 °C(lit.)
Boiling point 352.09°C (rough estimate)
density 1.1128 (rough estimate)
refractive index 1.6920 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Solubility Slightly soluble in water, ethanol, ether, chloroform
form Crystalline Powder
pka7.7(at 25℃)
color White to off-white
PH RangeBlue 0 uorescence (7.2) to yellow 0 uorescence (8.9)
Water Solubility Soluble in DMSO (100 mM), DMF (~1.5 mg/ml), ethanol (~1.5 mg/ml), and PBS (pH 7.2, ~0.25 mg/ml). Insoluble in water.
λmax241nm, 301nm, 336nm
Merck 14,4616
BRN 178813
Major ApplicationInks, antitumor agents, inhibition of cell proliferation, blocking breast and prostate cancer cells, tracer for ductal pancreatic cancer, DNA binding properties, treatment of neoplasia, antioxidants, therapy of depression, antileishmanial agent, treatment of parkinsonism, antiAIDS agents, antihypoxia agents, drugs, treatment of dependency disorder, psychiatric and neurological illness, antibiotics, antimalarial agents
InChIKeyBXNJHAXVSOCGBA-UHFFFAOYSA-N
LogP3.560
CAS DataBase Reference442-51-3(CAS DataBase Reference)
NIST Chemistry ReferenceHarmine(442-51-3)
Safety Information
Hazard Codes Xn
Risk Statements 25-36-20/21/22
Safety Statements 22-24/25-36/37-26-36
RIDADR 1544
WGK Germany 3
RTECS UV0175000
HazardClass 6.1
PackingGroup III
HS Code 29339900
MSDS Information
BANISTERINE MONOHYDRATE Usage And Synthesis
Chemical PropertiesOff-White Solid
Usesantiparkinsonian, CNS stimulant
Usescentral nervous system stimulant
UsesA CNS stimulant isolated from seeds of Peganum harmala L. Zygophyllaceae
DefinitionChEBI: A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.
General DescriptionThe combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.
storageStore at RT
Purification MethodsCrystallise harmine from MeOH and sublime it in a vacuum. See hydrochloride below. [Beilstein 23 II 348, 23 III/IV 2702, 23/12 V 237.]
BANISTERINE MONOHYDRATE Preparation Products And Raw materials
Raw materialsAcetic acid-->N,N-Dimethylformamide-->Phosphorus oxychloride-->Potassium hydroxide-->Ammonia-->Pyridine-->Piperidine-->Sodium sulfide-->Potassium dichromate-->Acetaldehyde-->Aluminium-nickel-->6-Methoxyindole-->Hydantoin
Preparation ProductsHARMOL-->HARMALINE
VERATRIDINE Xanthiside L-carnitine daurisoline HARMALOL 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Evodiamine Icariin menisdaurin HARMALINE 7-Methoxy-b-carboline-1-propionic acid HARMINE HYDROCHLORIDE Vasicine 9H-PYRIDO[3,4-B]INDOLE BANISTERINE MONOHYDRATE HARMINE METHYL IODIDE 9-METHOXYCANTHIN-6-ONE BROMOHARMINE HBR
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