Pramipexole dihydrochloride monohydrate

Pramipexole dihydrochloride monohydrate Basic information

Product Name:	Pramipexole dihydrochloride monohydrate
Synonyms:	Mirapex;(S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HClH2Otetrahydrobenzothiazol;Mirapex,Sifrol,Mirapexin;Pramipexole dihydrochloride monohydrate;(6S)-N'-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride;(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate;Pramipexole;2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)-
CAS:	191217-81-9
MF:	C10H20ClN3OS
MW:	265.8
EINECS:	687-708-9
Product Categories:	Inhibitors;Pramipexole;191217-81-9
Mol File:	191217-81-9.mol

Pramipexole dihydrochloride monohydrate Chemical Properties

Melting point	290 °C(dec.)
storage temp.	2-8°C
solubility	Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form	neat
color	White to Almost white
Merck	14,7705
BCS Class	1

Safety Information

MSDS Information

Pramipexole dihydrochloride monohydrate Usage And Synthesis

Chemical Properties	White or almost white, crystalline powder.
Uses	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses	Antidepressant; antiparkinsonian; antischizophrenic; dopamine agonist.
Definition	ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
Brand name	Mirapex (Boehringer Ingelheim).
General Description	Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clinical Use	Parkinson’s disease Symptomatic treatment of restless legs
Drug interactions	Potentially hazardous interactions with other drugs Avoid concomitant use with antipsychotics.
Metabolism	Pramipexole undergoes <10% metabolism to inactive metabolites. More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Pramipexole dihydrochloride monohydrate Preparation Products And Raw materials

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