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Trifluoroacetic anhydride

Trifluoroacetic anhydride Basic information
Product Name:Trifluoroacetic anhydride
Synonyms:TIFLUOROACETIC ANHYDRIDE;TRIFLUOROACETO ANHYDRIDE;Trifluoroacetic acid anhydride (TFAH);RIFLUOROACETIC ANHYDRIDE;Trifluoroacetic anhydride 10g [407-25-0];Trifluoroacetic anhy;Trifluoroacetic anhydride, min. 98%;trifluoroacetyl 2,2,2-trifluoroacetate
CAS:407-25-0
MF:C4F6O3
MW:210.03
EINECS:206-982-9
Product Categories:Pharmaceutical intermediates;Acylation Reagent;Halogen compounds;Organic Fluorides;Building Blocks;top;Acylation (GC Derivatizing Reagents);Analytical Chemistry;Fluorinated Building Blocks;organofluorine compound;Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Organic Building Blocks;Organics;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;GC Derivatizing Reagents;Synthetic Organic Chemistry;407-25-0;K00001
Mol File:407-25-0.mol
Trifluoroacetic anhydride Structure
Trifluoroacetic anhydride Chemical Properties
Melting point -65 °C (lit.)
Boiling point 39.5-40 °C (lit.)
density 1.511 g/mL at 20 °C (lit.)
vapor pressure 6.28 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Fp -26 °C
storage temp. 2-8°C
solubility Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
pka0.43[at 20 ℃]
form Liquid
color Clear
Specific Gravity1.487
Water Solubility Hydrolysis
Sensitive Moisture Sensitive
BRN 746197
Stability:Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
LogP0.79 at 25℃
CAS DataBase Reference407-25-0(CAS DataBase Reference)
NIST Chemistry ReferenceAcetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry SystemAcetic acid, trifluoro-, anhydride (407-25-0)
Safety Information
Hazard Codes C,T
Risk Statements 14-20-35-52/53-34-23/24/25
Safety Statements 26-36/37/39-43-45-61-9-8-28A-27
RIDADR UN 3265 8/PG 1
WGK Germany 2
RTECS AJ9800000
F 3-10
Hazard Note Corrosive/Moisture Sensitive
TSCA T
HazardClass 8
PackingGroup I
HS Code 29159080
Toxicityskn-rbt 500 mg/24H SEV 28ZPAK -,91,72
MSDS Information
ProviderLanguage
2,2,2-Trifluoroacetic anhydride English
SigmaAldrich English
ACROS English
ALFA English
Trifluoroacetic anhydride Usage And Synthesis
Chemical PropertiesClear, colorless liquid
UsesUsed as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
UsesTrifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Safety ProfileA severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification MethodsPurification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]
Trifluoroacetic anhydride Preparation Products And Raw materials
Raw materialsTrifluoroacetic acid-->DICHLOROACETIC ANHYDRIDE
Preparation ProductsChlorfenapyr-->2-Chloro-4-(trifluoromethyl)pyrimidine-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde-->(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine-->Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE-->ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE-->2-Hydroxymethyl-5-bromopyridine-->3-Nitroisonicotinic acid-->Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->5-Bromopyridine-2-carbaldehyde-->N10-(TRIFLUOROACETYL)PTEROIC ACID-->tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile-->2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID-->(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide-->3-CHLORO-5-NITROPYRIDINE-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine-->2,6-DICHLORO-4-ISOCYANATOPYRIDINE-->2-Hydroxy-4-(trifluoromethyl)pyrimidine-->2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid-->Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->2-(Bromomethyl)-6-methylpyridine-->2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE-->6-Aminobenzothiazole-->5-Iodo-2,4-dimethoxypyrimidine-->2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-->2-(TRIFLUOROACETYL)THIOPHENE-->[Bis(trifluoroacetoxy)iodo]benzene-->3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-->2-CYANO-4-PYRIDINE CARBOXYLIC ACID-->Epirubicin
Trifluoromethanesulfonic anhydride 2,2,2-TRIFLUOROETHYL METHYL ETHER 2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE DIFLUOROACETIC ANHYDRIDE Acetic anhydride Ethyl difluoroacetate Ethyl fluoroacetate Difluoroethane TRIFLUOROACETALDEHYDE Formic acid Succinic anhydride Ethyl trifluoroacetate Trifluoroacetic anhydride Trifluoromethane Glutaric anhydride Methyl fluoroacetate Isatoic Anhydride 2-Fluoroethanol Trifluoroacetic Acid Anhydride
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