ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluoroaniline series 2-Fluoroaniline

2-Fluoroaniline

2-Fluoroaniline Basic information
Product Name:2-Fluoroaniline
Synonyms:LABOTEST-BB LTBB000714;FLUOROANILINE-2;2-Fluoroaniline o-Fluoroaniline;2-FLUOROANILINE, 99+%;2-FluoroanilineForSynthesis;2-Fluoroaniline99.5%;Aniline, 2-fluoro-;Aniline, o-fluoro-
CAS:348-54-9
MF:C6H6FN
MW:111.12
EINECS:206-478-9
Product Categories:Fluoro-Aromatics;Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene;Heterocyclic Compounds;Benzene derivatives;Fluorobenzene Series;Fluorine series;amine | alkyl Fluorine
Mol File:348-54-9.mol
2-Fluoroaniline Structure
2-Fluoroaniline Chemical Properties
Melting point -29 °C
Boiling point 182-183 °C(lit.)
density 1.151 g/mL at 25 °C(lit.)
vapor pressure 1 hPa (20 °C)
refractive index n20/D 1.544(lit.)
Fp 140 °F
storage temp. Store below +30°C.
solubility 17g/l
pka3.2(at 25℃)
form Liquid
color Clear colorless
Specific Gravity1.151
Water Solubility 17 g/L (20°C)
BRN 1524219
CAS DataBase Reference348-54-9(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, 2-fluoro-(348-54-9)
EPA Substance Registry Systemo-Fluoroaniline (348-54-9)
Safety Information
Hazard Codes Xn,T,Xi
Risk Statements 22-37/38-41-36/38-33-23/24/25
Safety Statements 26-39-37/39-45-36/37-28
RIDADR UN 2941 6.1/PG 3
WGK Germany 2
RTECS BY1390000
Autoignition Temperature600 °C
Hazard Note Toxic/Irritant
TSCA T
HazardClass 6.1
PackingGroup III
HS Code 29214210
MSDS Information
ProviderLanguage
1-Amino-2-fluorobenzene English
SigmaAldrich English
ACROS English
ALFA English
2-Fluoroaniline Usage And Synthesis
Chemical Properties2-Fluoroaniline is a clear colorless to brown liquid, toxic, insoluble in water, soluble in ethanol and ether, its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of fire and high heat. Reacts with oxidants. Decomposed by high heat to release toxic gases.
Uses2-Fluoroaniline (cas# 348-54-9) is a useful reagent for the synthesis of insecticides.
Application2-Fluoroaniline can be used to synthesize thermosensitive dye FH-102, which is a black thermosensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, EEG recording paper, telephone fax paper and transparent thermal film for oil field.
DefinitionChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.
Synthesis Reference(s)Tetrahedron Letters, 25, p. 3415, 1984 DOI: 10.1016/S0040-4039(01)91034-2
General DescriptionClear liquid with a mild sweet odor. Sinks in and mixes slowly with water.
Air & Water ReactionsWater soluble.
Reactivity Profile2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health HazardInhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.
Fire HazardSpecial Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires.
Metabolic pathway2-Fluoro and 3-fluoroanilines are preferentially hydroxylated at the para-position, and 4-fluoroaniline is both p- and o-hydroxylated to a significant extent by rat liver microsomes and is not accompanied with an NIH shift to give 4-hydroxyl-3-fluoroaniline.
2-BENZOYLACETANILIDE N-(4-FLUOROBENZYLIDENE)-4-FLUOROANILINE NN-BIS(2-HYDROXYETHYL)-M-FLUOROANILINE 3-CHLORO-5-FLUOROANILIN N-(2-[3-(BENZYLSULFANYL)-6-METHYL-1,2,4-TRIAZIN-5-YL]VINYL)-4-FLUOROANILINE 2-BROMO-4,5,6-TRIFLUOROANILINE ALTRENOGEST N-(CHLOROACETYL)-3-FLUOROANILINE 2-choro-4-fluoroaniline 3-Bromo-2-Chloro-4-Fluoroaniline N,N-DIMETHYL-3-FLUOROANILINE 4-BROMO-2-FLUOROANILINE, TECH N-METHYL-2-FLUOROANILINE N-(4-METHOXYBENZYLIDENE)-4-FLUOROANILINE AMINO ACIDS 2-([1,1'-BIPHENYL]-2-YLOXY)-5-FLUOROANILINE N-(CHLOROACETYL)-2-FLUOROANILINE 2,4,5-TRIFLUORO-6-BROMOANILINE
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