ChemicalBook Product Catalog Inorganic chemistry Inorganic salts Phosphide And metal phosphates METHYLENEDIPHOSPHONIC ACID

METHYLENEDIPHOSPHONIC ACID

METHYLENEDIPHOSPHONIC ACID Basic information
Product Name:METHYLENEDIPHOSPHONIC ACID
Synonyms:[α,β-Methylene]diphosphoric acid;Methylenediphosphonic acid, Medronic acid;Medronic acid, Methanediylbis(phosphonic acid);Methylenediphosphonic acid, methylene diphosphoric acid, Methylenediphosphonic Acid;Phosphonic acid, P , P '-methylenebis-;Methylene diphosphophonic acid;Methylenediphosphonic acid 99%;methylenediphosphonate
CAS:1984-15-2
MF:CH6O6P2
MW:176
EINECS:217-851-0
Product Categories:Building Blocks;Chemical Synthesis;Analytical Chemistry;Organic Building Blocks;Phosphonic/Phosphinic Acids;Phosphorus Compounds;Ligands for Pharmaceutical Research;Radiopharmaceutical Chemistry (Chelating Reagents);Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:1984-15-2.mol
METHYLENEDIPHOSPHONIC ACID Structure
METHYLENEDIPHOSPHONIC ACID Chemical Properties
Melting point 197-199 °C(lit.)
Boiling point 583.2±60.0 °C(Predicted)
density 2.111±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO : 250 mg/mL (1420.45 mM; Need ultrasonic)
form Moist Crystals or Crystalline Powder
pka1.43±0.10(Predicted)
color Blue
Water Solubility Soluble in water.
Merck 14,5792
BRN 1708494
InChIKeyMBKDYNNUVRNNRF-UHFFFAOYSA-N
CAS DataBase Reference1984-15-2(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 3261 8/PG 3
WGK Germany -
RTECS SZ9138000
F 3
HazardClass 8
PackingGroup III
HS Code 29319019
ToxicityLD50 in mice, rabbits (mg/kg): 45-50 i.v. (Subramanian, 1975)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
METHYLENEDIPHOSPHONIC ACID Usage And Synthesis
Chemical PropertiesColourless solid
UsesRadioactive imaging agent
UsesMethylenediphosphonic acid is a radioactive compound used for skeletal imaging. MDP has been used as a chelating agent to vary calcium levels in cell culture in a study of caffeine storage in bovine chromaffin cells.
UsesMethylenediphosphonic acid can be used as a precursor in the synthesis of:
  • Mesoporous aluminum organophosphonate in the presence of alkyltrimethylammonium as a surfactant.
  • Tetraester of methylenediphosphonic acids which are used as metal ion extractants for actinides in all oxidation states.

DefinitionChEBI: A 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups.
General DescriptionMDP (Methylenediphosphonic acid) is a phosphonic analog of ATP.
METHYLENEDIPHOSPHONIC ACID Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Tetraisopropyl methylenediphosphonate
Preparation ProductsTiludronic acid-->METHYLENEBIS(PHOSPHONIC DICHLORIDE)
METHYLENEDIPHOSPHONIC ACID TETRAISOPROPYL ESTER ALPHA,BETA-METHYLENEADENOSINE 5'-DIPHOSPHATE SODIUM SALT 2-[1-(5,5-DIMETHYL-2-OXO-1,3,2LAMBDA5-DIOXAPHOSPHINAN-2-YL)VINYL]-5,5-DIMETHYL-1,3,2LAMBDA5-DIOXAPHOSPHINAN-2-ONE TETRAISOPROPYL DICHLOROMETHYLENE DIPHOSPHONATE (aminomethylene)bisphosphonic acid ALPHA,BETA-METHYLENEADENOSINE 5'-TRIPHOSPHATE LITHIUM SALT ALPHA,BETA-METHYLENEGUANOSINE 5'-DIPHOSPHATE SODIUM SALT ALPHA,BETA-METHYLENEADENOSINE 5'-DIPHOSPHATE CBI-BB ZERO/001488 L-690,330 TETRAETHYL DIMETHYLAMINOMETHYLENEDIPHOSPHONATE 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID TRISODIUM SALT Tetraethylfluoromethylene-diphosphonate 2-[(5,5-DIMETHYL-2-OXO-1,3,2LAMBDA5-DIOXAPHOSPHINAN-2-YL)METHYL]-5,5-DIMETHYL-1,3,2LAMBDA5-DIOXAPHOSPHINAN-2-ONE METHYLENEDIPHOSPHONIC ACID TRISODIUM SALT ADENYLYLMETHYLENEDIPHOSPHONATE SODIUM SALT METHYLENEDIPHOSPHONIC ACID TETRAETHYL ESTER,Bis(diethoxyphosphinyl)methane, Methylenediphosphonic acid tetraethylester TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT
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