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| | 4-tert-Octylphenol Basic information |
| | 4-tert-Octylphenol Chemical Properties |
| Melting point | 79-82 °C(lit.) | | Boiling point | 175 °C30 mm Hg(lit.) | | density | 0.95 g/cm3 (20℃) | | vapor pressure | 2Pa at 38℃ | | refractive index | 1.5003 (estimate) | | Fp | 145 °C | | storage temp. | -20°C | | solubility | water: slightly soluble0.007g/L at 20°C | | form | neat | | pka | 10.15±0.15(Predicted) | | color | White flakes | | PH Range | 6 at 10 g/l at 20 °C | | Water Solubility | 7mg/L at 20℃ | | BRN | 513992 | | Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. | | LogP | 4.8 at 22℃ | | CAS DataBase Reference | 140-66-9(CAS DataBase Reference) | | NIST Chemistry Reference | Phenol, 4-(1,1,3,3-tetramethylbutyl)-(140-66-9) | | EPA Substance Registry System | p-(1,1,3,3-Tetramethylbutyl)phenol (140-66-9) |
| | 4-tert-Octylphenol Usage And Synthesis |
| Chemical Properties | white powder | | Uses | 4-tert-Octylphenol (4t-OP) is used in manufacturing processes as an intermediate in the generation of surfactants, synthetic rubber additives, or resins. 4t-OP is also used to manufacture alkylphenol ethoxylates. It is found mainly in detergents, cleaning products, and emulsifiers and less frequently in paints, personal care products, pesticides, paper, pulp, and textiles. | | Definition | ChEBI: 4-tert-Octylphenol is an alkylbenzene. | | General Description | 4-tert-Octylphenol is a potential environmental pollutant and it exhibits toxic and estrogenic effects on mammalian cells. It binds to estrogen receptors and exerts estrogenic actions in vitro. The transformation of the 4-tert-octylphenol upon irradiation at 253.7nm and by hydroxyl radicals generated by the photolysis (λexc = 253.7nm) of hydrogen peroxide in aqueous solution has been studied. | | Health effects | 4-tert-octylphenol (OP) is an endocrine-disrupting chemical that causes harmful effects to human health.a common environmental pollutant showing weak estrogenic effects. 4-tert-Octylphenol has been shown to cause harm to the male reproductive system of vertebrates.
High doses of several alkylphenols, including 4- tert-octylphenol, have altered estrogenic effects, including sex hormone levels, estrus cycles, reproductive outcomes, neonatal sexual development, as well as impaired production of steroid hormone and testicular atrophy. | | Environmental Fate | Studies have shown that 4t-OP will adsorb to sediments. | | Purification Methods | Crystallise the phenol from n-hexane and/or distil it in a vacuum. [Beilstein 6 III 2051, 6 IV 3484.] | | Toxicity evaluation | 4t-OP has been shown to be an estrogen receptor (ER) agonist.
Estrogenic effects of 4t-OP have been demonstrated in human
cells, with 4t-OP displacing the natural estrogen 17b estradiol
from its receptor, and 4t-OP inducing cell proliferation in
estrogen-dependent cell proliferation assays. In vivo confirmation
of 4t-OP’s estrogenicity has been confirmed with the uterotrophic
assay. |
| | 4-tert-Octylphenol Preparation Products And Raw materials |
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