ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Ethylpyridine 2-(2-Hydroxyethyl)pyridine

2-(2-Hydroxyethyl)pyridine

2-(2-Hydroxyethyl)pyridine Basic information
Product Name:2-(2-Hydroxyethyl)pyridine
Synonyms:2-ETHANOLPYRIDINE;2-(B-HYDROXYETHYL)PYRIDINE;2-(2-hydroxyethyl)-pyridin;2-(2-Pyridinyl)ethanol;2-(alpha-pyridyl)ethanol;2-PYRIDINEETHANOL;2-PYRIDYLETHANOL;2-PYRIDIN-2-YL-ETHANOL
CAS:103-74-2
MF:C7H9NO
MW:123.15
EINECS:203-140-2
Product Categories:Aromatics, Heterocycles, Intermediates, Metabolites & Impurities;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine;Amino Acid Derivatives;bc0001
Mol File:103-74-2.mol
2-(2-Hydroxyethyl)pyridine Structure
2-(2-Hydroxyethyl)pyridine Chemical Properties
Melting point -8--7°C
Boiling point 114-116 °C/9 mmHg (lit.)
density 1.093 g/mL at 25 °C (lit.)
vapor pressure 1.16-14.1Pa at 25℃
refractive index n20/D 1.537(lit.)
Fp 199 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in Chloroform (Slightly), Methanol (Slightly).
form Liquid
pka14.49±0.10(Predicted)
color Clear yellow to brown
PH8-9 (100g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
BRN 111205
LogP0.38
CAS DataBase Reference103-74-2(CAS DataBase Reference)
NIST Chemistry Reference2-Pyridineethanol(103-74-2)
EPA Substance Registry System2-Pyridineethanol (103-74-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 2
RTECS UT2970450
F 3
TSCA Yes
HS Code 29333999
Hazardous Substances Data103-74-2(Hazardous Substances Data)
MSDS Information
ProviderLanguage
2-(2-Pyridyl)ethanol English
SigmaAldrich English
ACROS English
ALFA English
2-(2-Hydroxyethyl)pyridine Usage And Synthesis
Chemical Propertiesclear yellow to brown liquid
Uses2-Pyridineethanol is a metabolite of the anti-vertigo drug Betahistine (B324000).
Uses2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.
General Description2-(2-pyridyl)ethanol derivatives react with the aryl and alkenyl chlorides (palladium-catalyzed reactions) that result in the substitution of the chloro moieties with a 2-pyridylmethyl group.
2-(2-Hydroxyethyl)pyridine Preparation Products And Raw materials
Preparation ProductsBetahistine-->2-Vinylpyridine-->2-Piperidineethanol-->2-(2-BROMO-ETHYL)-PYRIDINE HYDROBROMIDE-->2-Picolinic acid-->2-Pyridin-2-ylethyl acetate-->Betahistine dihydrochloride-->2-Pyridineethanamine, N-(1-methylethyl)--->METHANESULFONATE-2-PYRIDINEETHANOL ESTER-->2-(1-oxidopyridin-1-ium-2-yl)ethanol
2-Pyridylacetic acid hydrochloride Ethyl 2-pyridylacetate METHYL 2-PYRIDYLACETATE 2-(2-ISOPROPOXYETHYL)PYRIDINE, 99 2,3-DI-2-PYRIDYL-2,3-BUTANEDIOL, 99%, MIXTURE OF (+/-) AND MESO 2-(Hydroxymethyl)pyridine 2-(2-ETHOXYETHYL)PYRIDINE ALPHA-PYRIDOIN Hydroxyethyl starch 2-(2-Hydroxyethyl)pyridine Clopidol 2-(B-ETHOXYETHYL)-6-METHYLPYRIDINE 2-(2-METHOXYETHYL)PYRIDINE 2,5-Dimethylpyridine Sodium isethionate Pyridine 1,2-DIPYRIDIN-2-YLETHANE-1,2-DIOL 2-(2-propoxyethyl)pyridine
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