Mosapride citrate

Mosapride citrate Basic information
Product Name:Mosapride citrate
Synonyms:4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE;4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate;Gasmotin;enzamidecitrate;yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1);4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate;4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
CAS:112885-42-4
MF:C27H33ClFN3O10
MW:614.02
EINECS:601-211-6
Product Categories:Inhibitors;APIS;Gastroprokinetic Agent;API;TAK-370, AS-4370, Gasmotin
Mol File:112885-42-4.mol
Mosapride citrate Structure
Mosapride citrate Chemical Properties
Melting point 143-145°
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated)
form Solid
color White to Off-White
Stability:Hygroscopic
CAS DataBase Reference112885-42-4(CAS DataBase Reference)
Safety Information
ToxicityLD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)
MSDS Information
Mosapride citrate Usage And Synthesis
DescriptionMosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
UsesAs a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
UsesMosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.
Biological Activity5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
storageroom temperature (desiccate)
Mosapride citrate Preparation Products And Raw materials
Raw materialsMosapride-->Citric acid
Mosapride (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE 3-Hydroxyazetidine hydrochloride AKOS BC-2739 4-amino-N-((4-benzyl-2-morpholinyl)-methyl)-5-chloro-2-ethoxybenzamide (2-METHOXY-BENZYL)-(2-METHOXY-ETHYL)-AMINE N-(2-HYDROXYETHYL)SALICYLAMIDE, 98 5-CHLORO-2-ETHOXY-BENZENEMETHANAMINE (4-BENZYL-MORPHOLIN-2-YLMETHYL)-METHYL-AMINE Morpholin-2-yl-methylamine 2-(4-FLUOROBENZYLAMINO)ETHANOL (4-BENZYL-MORPHOLIN-2-YLMETHYL)-ETHYL-AMINE CHEMBRDG-BB 9071797 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine 2-Methylmorpholine Mosapride citrate METHYL-MORPHOLIN-2-YLMETHYL-AMINE Ammonium citrate tribasic

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.