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| | D-Tyrosine Chemical Properties |
| Melting point | >300 °C (lit.) | | alpha | 11.3 º (c=5, 1N HCl) | | Boiling point | 314.29°C (rough estimate) | | density | 1.2375 (rough estimate) | | refractive index | 11.2 ° (C=5, 1mol/L HCl) | | storage temp. | Store at RT. | | solubility | Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly) | | form | Crystals or Powder | | pka | 2.25±0.10(Predicted) | | color | White to off-white | | optical activity | [α]20/D +10.3°, c = 5 in 1 M HCl | | Water Solubility | SOLUBLE | | Merck | 14,9839 | | BRN | 2212157 | | InChIKey | OUYCCCASQSFEME-UHFFFAOYSA-N | | LogP | -0.418 (est) | | CAS DataBase Reference | 556-02-5(CAS DataBase Reference) | | EPA Substance Registry System | D-Tyrosine (556-02-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29225000 |
| | D-Tyrosine Usage And Synthesis |
| Description | D-tyrosine is the D-form amino acid of tyrosine. It is a non-essential amino acid. In animals, it can be de novo synthesized from phenylalanine. It is also the precursor of epinephrine, thyroid, hormones and melanin. Specially, study has shown that it can be taken s a chiral precusor to potent inhibitors of human Nonpancreatic secretory phospholipase A 2(IIa) with strong anti-inflammatory activity. It can also be used as a starting material for the preparation of anisomycin.
| | References | https://pubchem.ncbi.nlm.nih.gov/compound/D-tyrosine#section=Top
Dr, Karl A. Hansford, et al. "D -Tyrosine as a Chiral Precusor to Potent Inhibitors of Human Nonpancreatic Secretory Phospholipase A 2, (IIa) with Anti-inflammatory Activity." Chembiochem 4.2-3(2003):181.
Jegham, Samir, and B. C. Das. "A new synthesis of (−)-anisomycin or (+)-anisomycin starting from D-tyrosine or L-tyrosine." Tetrahedron Letters 29.35(1988):4419-4422.
| | Chemical Properties | white to off-white powder | | Uses | D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid
transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic po
lypropylene surfaces. | | Uses | D-Tyrosine is synthesized from phenylalanine. It is also the precursor of epinephrine, thyroid hormones, and melanin. | | Definition | ChEBI: An optically active form of tyrosine having D-configuration. |
| | D-Tyrosine Preparation Products And Raw materials |
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