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| | Isoflupredone Basic information |
| Product Name: | Isoflupredone | | Synonyms: | ISOFLUPREDONE;DELTAFLUDROCORTISONE;9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11b)-;Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-;1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE;1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE;9-FLUOROPREDNISOLONE | | CAS: | 338-95-4 | | MF: | C21H27FO5 | | MW: | 378.43 | | EINECS: | 206-422-3 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 338-95-4.mol |  |
| | Isoflupredone Chemical Properties |
| Melting point | 260-262°C (dec.) | | alpha | D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried) | | Boiling point | 566.7±50.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly) | | pka | 12.10±0.70(Predicted) | | form | Solid | | color | White to Pale Brown |
| | Isoflupredone Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Isoflupredon,Farmabios | | Uses | Anti-inflammatory. | | Definition | ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid. | | Manufacturing Process | A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml
of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml
Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of
Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for
24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α-
fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated
with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The
culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to
dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene-
11β,17α,21-triol-3.20-dione as a solid. | | Therapeutic Function | Glucocorticoid |
| | Isoflupredone Preparation Products And Raw materials |
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