Diethyl methylmalonate

Diethyl methylmalonate Basic information
Product Name:Diethyl methylmalonate
Synonyms:RARECHEM AL BI 0301;Diethyl methylmalonate 99%;DIETHYL METHYLMALONATE;DIETHYL 2-METHYLPROPANEDIOATE;1,3-Diethyl 2-methylpropanedioate;Diethyl methylmalote;Methoxymalonic Acid Diethyl Ester;Methylmalonic acid diethyl ester~Methylpropanedioic acid diethyl ester
CAS:609-08-5
MF:C8H14O4
MW:174.19
EINECS:210-175-7
Product Categories:Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Pharmaceutical Intermediates;Cyanoacetic acid esters;Hydrocyanic acid derivatives;bc0001
Mol File:609-08-5.mol
Diethyl methylmalonate Structure
Diethyl methylmalonate Chemical Properties
Boiling point 198-199 °C (lit.) 78-80 °C/10 mmHg
density 1.022 g/mL at 20 °C (lit.)
refractive index n20/D 1.413(lit.)
Fp 170 °F
storage temp. Sealed in dry,Room Temperature
solubility 1000mg/l
form Liquid
pka13.13±0.46(Predicted)
Specific Gravity1.013
color Clear colorless
PH8 (1000mg/l, H2O, 20℃)
Water Solubility immiscible
BRN 637028
InChIKeyUPQZOUHVTJNGFK-UHFFFAOYSA-N
LogP1.256 (est)
CAS DataBase Reference609-08-5(CAS DataBase Reference)
NIST Chemistry ReferencePropanedioic acid, methyl-, diethyl ester(609-08-5)
EPA Substance Registry SystemPropanedioic acid, methyl-, diethyl ester (609-08-5)
Safety Information
Safety Statements 23-24/25
WGK Germany 3
TSCA Yes
HS Code 29171990
MSDS Information
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Diethyl methylmalonate English
SigmaAldrich English
ACROS English
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Diethyl methylmalonate Usage And Synthesis
Chemical PropertiesClear liquid
UsesDiethyl methylmalonate was used to investigate the effect of direct supplementation of the medium with di-ester of methylmalonate on erythromycin fermentation in Saccharopolyspora erythraea mutB strain.
UsesDiethyl methylmalonate is used as intermediate for the syntheses of pharmaceuticals, e.g. non-steroidal anti-inflammatory agents with 2-acrylpropionic acid structures acrylpropionic acid structure. It is also used in the flavour and fragrance industries. Product Data Sheet
General DescriptionDiethyl methylmalonate reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone. It causes the alkylation of poly(chloromethylstyrene) during pahse transfer catalysis.
flurbiprofen 4-Acetyl-2-fluorobiphenyl Flurbiprofen Impurity 8 Flurbiprofen Impurity 15 2,4-Difluorobiphenyl diethyl (3-fluoro-4-nitrophenyl)methylmalonate 4'-hydroxyflurbiprofen 2-Fluorobiphenyl-4-carboxylic Acid Flurbiprofen Impurity Flurbiprofen Related Impurity 1 4-ETHYL-2-FLUORO-1,1'-BIPHENYL diethyl (4-amino-3-fluorophenyl)methylmalonate 2-Methylpropanedioic acid DIETHYL METHYLMALONATE, [2-14C] Methyl DIETHYL (CARBOXYMETHYLAMINO)METHYLENEMALONATE BUTYL OLEATE DIETHYL METHYLMALONATE, (METHYLMALONIC ACID DIETHYL ESTER)

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