SITS

SITS Basic information
Product Name:SITS
Synonyms:disodium 5-acetamido-2-[2-(4-isothiocyanato-2-sulphonatophenyl)vinyl]benzenesulphonate;4-ACETAMIDO-4'-ISOTHIOCYANATO-STILBENE-2 ,2'-DISULF.ACID-NA;4-ACETAMIDO-4'-ISOTHIOCYANATOSTILBENE-2- 2'-DISULFO;acetamidoisothiocyanato-stilbenedisulfonic acid disodium;4-Acetamido-4μ-isothiocyanato-2,2μ-stilbenedisulfonic acid hydrate disodium salt;SITS, Disodium 4-acetamido-4μ-isothiocyanato-stilben-2,2μ-disulfonate;4-Acetylamino-4'-isothiocyanatostilbene-2,2'-disulfonic acid disodium salt;5-(Acetylamino)-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid disodium salt
CAS:51023-76-8
MF:C17H12N2Na2O7S3
MW:498.46
EINECS:256-919-4
Product Categories:Aromatics;Sulfur & Selenium Compounds;Stilbene;marker;Fluorescent Labels & Indicators
Mol File:51023-76-8.mol
SITS Structure
SITS Chemical Properties
Melting point >300°C (dec.)
storage temp. -20°C
solubility Soluble in water, methanol, dimethyl sulfoxide
form powder
color Yellow or tan-yellow
λmax336 nm
BRN 9177451
Stability:Temperature sensitive - recommended storage at -20oC
Biological ApplicationsChloride channel blockers; anion transport inhibitors; treating cancer,glaucoma,heart diseases,viral diseases
CAS DataBase Reference51023-76-8(CAS DataBase Reference)
EPA Substance Registry SystemBenzenesulfonic acid, 5-(acetylamino)-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]-, disodium salt (51023-76-8)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38-42
Safety Statements 22-26-36/37
WGK Germany 3
8-10-21
HS Code 2930909899
MSDS Information
ProviderLanguage
SigmaAldrich English
SITS Usage And Synthesis
Chemical PropertiesLight Yellow Solid
UsesFluorescent marker for membranes; inhibits anion permeability of membranes. Also inactivates Na,K-ATPase, by covalent modification of a specific Lys residue.
UsesA fluorescent label for the specific and reversible labelling of the outer components of the plasma membrane. The reagent reacts with a fixed number of sites on the surface of cells concerned with anion permeation; does not pass through the osmotic barrier of the membrane; reacts under physiological conditions of temperature, pH and tonicity; and is detectable in small amounts. SEE ALSO NOTES FOR DIDS (CAT#D460600). Fluorescence: max. Abs. l = 336nm, max. Em. l = 436 nm.
SITS Preparation Products And Raw materials
SITS (Primuline) 4-AMINOSTILBENE 4,4'-DIAMINOSTILBENE DIHYDROCHLORIDE SITS AMINE 4,4'-Diamino-2,2'-stilbenedisulfonic acid o-Toluenesulfonic acid, sodium salt 4-METHYLFORMANILIDE SITS (Stilbene Isothiosulphonic Acid) 4-Methylphenyl isothiocyanate 4-ACETAMIDO-4'-ISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID, SODIUM SALT [SITS] TRANS-STILBENE p-Acetotoluidide SITS:Ion Channels SITS 5-Amino-2-methylbenzenesulfonic acid TRANS-4-AMINOSTILBENE TRANS-4-ACETYL-AMINOSTILBENE 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulphonic acid, sodium salt [SITS]

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