ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide

4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide

4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Basic information
Product Name:4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide
Synonyms:4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide;2-Pyridinecarboxamide, 4-[3-fluoro-4-[[2-[(methylamino)carbonyl]-4-pyridinyl]amino]phenoxy]-N-methyl-;Regorafenib Dipyrimidine;4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide formate;Regorafenib Impurities69;Azilsartan medoxomil impurity263;Regorafenib Impurities04;Regorafenib Impurities11
CAS:1855006-12-0
MF:C20H18FN5O3
MW:395.39
EINECS:
Product Categories:
Mol File:1855006-12-0.mol
4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Structure
4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Chemical Properties
Boiling point 631.8±55.0 °C(Predicted)
density 1.329±0.06 g/cm3(Predicted)
pka13.92±0.46(Predicted)
Safety Information
MSDS Information
4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Usage And Synthesis
UsesRegorafenib Dipyrimidine is an impurity of Regorafenib(R143000); which inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.
4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Preparation Products And Raw materials
Regorafenib Impurity 16 INDEX NAME NOT YET ASSIGNED 4-(4-amino-3-(4-amino-3-(4-amino-3-fluorophenoxy)phenoxy)phenoxy)-N-methylpicolinamide Regorafenib Impurity 17 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]phenoxy]-N-methyl- Regorafenib Impurity 6 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE N-Desmethyl Regorafenib Regorafenib Impurity 10 Regorafenib Impurity 9 Regorafenib Impurity 13 N-Desmethyl Regorafenib N-Oxide (M5 Metabolite) 2-Pyridinecarboxamide, 4-[2-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
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