| | Ethyl trifluoroacetate Basic information |
| | Ethyl trifluoroacetate Chemical Properties |
| Melting point | -78 °C | | Boiling point | 60-62 °C(lit.) | | density | 1.194 g/mL at 25 °C(lit.) | | vapor pressure | 18.5kPa at 20℃ | | refractive index | n20/D 1.307(lit.) | | Fp | 30 °F | | storage temp. | 2-8°C | | solubility | 4g/l | | pka | 0.43[at 20 ℃] | | form | Liquid | | color | Clear | | Specific Gravity | 1.194 | | PH | 4 (4g/l, H2O, 20℃) | | Water Solubility | HYDROLYSIS | | Sensitive | Moisture Sensitive | | BRN | 1761411 | | Stability: | Hygroscopic, Moisture Sensitive, Volatile | | InChIKey | STSCVKRWJPWALQ-UHFFFAOYSA-N | | LogP | 0.79-1.032 at 25℃ | | CAS DataBase Reference | 383-63-1(CAS DataBase Reference) | | NIST Chemistry Reference | Acetic acid, trifluoro-, ethyl ester(383-63-1) | | EPA Substance Registry System | Ethyl trifluoroacetate (383-63-1) |
| | Ethyl trifluoroacetate Usage And Synthesis |
| Chemical Properties | Colorless to yellow liquid | | Uses | Widely used in the synthetic process of medicine, pesticides and organic intermediate. | | Uses | Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri
fluoroacylated compounds. | | Uses | Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds. | | Definition | ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid. | | Synthesis Reference(s) | Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056 | | Flammability and Explosibility | Highlyflammable | | Purification Methods | Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.] |
| | Ethyl trifluoroacetate Preparation Products And Raw materials |
| Raw materials | Trifluoroacetic acid-->Ethyl trifluoromethanesulfonate | | Preparation Products | 6,7-DIMETHOXY-3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE-->HEXAFLUOROACETYLACETONE-->METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE-->2-AMINO-6-T-BUTYL-4-(TRIFLUOROMETHYL)PYRIMIDINE-->2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE-->2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-CARBOXALDEHYDE-->EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE-->3-TRIFLUOROACETYL-D-CAMPHOR-->Efavirenz-->1,1,1-Trifluoro-2-hexanone-->8-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBONITRILE-->4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE-->4,4,4-Trifluoro-1-phenyl-1,3-butanedione-->BENZALDEHYDE DIETHYL ACETAL-->1,1,1-TRIFLUORO-5,5-DIMETHYL-2,4-HEXANEDIONE-->2-(TRIFLUOROMETHYL)PYRIMIDINE-4,6-DIOL-->3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE-->3-PHENYL-1,1,1-TRIFLUOROPROPAN-2-ONE-->1-(2-AMINO-5-CHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE |
|
