ChemicalBook Product Catalog Chemical Reagents Organic reagents Cyanate ester / isocyanate (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate Basic information
Product Name:(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
Synonyms:ATS-8;(4R,6R)-T-BUTYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE;(4R,6R)-TERT-BUTYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE;(4R,CIS)-1,1-DIMETHYLETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE;(4R,3R)-TERT-BUTYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE;(4R-CIS)-1,1-DIMETHYLETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATS-8);tert-Butyl (4R,3R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate;TERT-BUTYL[(4R,6R)-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXAN-4-YL]ACETATE
CAS:125971-94-0
MF:C14H23NO4
MW:269.34
EINECS:425-780-3
Product Categories:INTERMEDIATESOFATORVASTATIN;chiral;Chemical intermediate for Atorvastatin Calcium;(intermediate of atorvastatin);Chiral Building Blocks;Atorvastatin intermediates;Cyanides/Nitriles;Organic Building Blocks
Mol File:125971-94-0.mol
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate Structure
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate Chemical Properties
Melting point 65-69 °C(lit.)
Boiling point 364.1±17.0 °C(Predicted)
density 1.016±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility soluble in Chloroform
form powder to crystal
color White to Almost white
optical activity[α]20/D 1.0°, c = 1 in chloroform
CAS DataBase Reference125971-94-0(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29329990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powde
UsesAtorvastatin Intermediate
Uses(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is an intermediate of Atorvastatin (A791750, Ca salt), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate Preparation Products And Raw materials
Preparation Products(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester-->Atorvastatin Acetonide tert-Butyl Ester
Dimethylbenzylcarbinyl acetate CYANOGEN tert-Butyl acetate N,N-Dimethylformamide 1,2-Dioxane ETHANE tert-Butanol tert-Butyl peroxyacetate 4R-Cis-Tert-Butyl-6-CyanoMethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate Butyl acetate Dimethyl fumarate Methyl 2,2-dimethylphenylacetate tert-Butyl chloroacetate DL-sec-Butyl acetate tert-Butyl bromoacetate Dimethyl sulfoxide Isobutyl acetate
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