|
| Product Name: | UM729 | | Synonyms: | UM729;C07;methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate;4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester;CS-1240;UM-729;UM 729;9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester;UM729 USP/EP/BP | | CAS: | 1448723-60-1 | | MF: | C20H25N5O2 | | MW: | 367.44 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1448723-60-1.mol |  |
| | UM729 Chemical Properties |
| | UM729 Usage And Synthesis |
| Biological Activity | UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists. | | in vitro | um729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, and UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased CD34+CD15- Number of cells. It can inhibit the differentiation of most AML cells in combination with AhR antagonists. | | in vivo | In NSG mice, UM729, alone or in combination with SR1, enhanced engraftment but not leukemia stem cell (LSC) frequency distribution. |
| | UM729 Preparation Products And Raw materials |
|
