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APIGENIN-7-GLUCURONIDE

APIGENIN-7-GLUCURONIDE Basic information
Product Name:APIGENIN-7-GLUCURONIDE
Synonyms:APIGENIN-7-GLUCURONIDE;APIGENIN-7-O-GLUCURONIDE;4',5-Dihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone;5,4'-Dihydroxy-7-(β-D-glucopyranuronosyloxy)flavone;7-(6-Oxo-β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Apigenin 7-O-β-D-glucuronide;Glucuronyl-7-apigenin;Apigenin 7-glucuronide(Apigenin-7-O-β-D-glucuronide)
CAS:29741-09-1
MF:C21H18O11
MW:446.36
EINECS:
Product Categories:Miscellaneous Natural Products
Mol File:29741-09-1.mol
APIGENIN-7-GLUCURONIDE Structure
APIGENIN-7-GLUCURONIDE Chemical Properties
Melting point >300℃
Boiling point 841.8±65.0 °C(Predicted)
density 1.737
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO : 65 mg/mL (145.62 mM; Need ultrasonic)
form powder
pka2.73±0.70(Predicted)
color Yellowish
InChIKeyJBFOLLJCGUCDQP-ZFORQUDYSA-N
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
APIGENIN-7-GLUCURONIDE Usage And Synthesis
UsesApigenin 7-Glucuronide is a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.
DefinitionChEBI: Apigenin 7-glucuronide is a member of flavonoids and a glucosiduronic acid.
targetNO | PGE | TNF-α | NOS | COX | AP-1 | ERK | p38MAPK | MMP-3 | MMP-8 | MMP-9 | MMP-13
APIGENIN-7-GLUCURONIDE Preparation Products And Raw materials
2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Apigenin Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers) Apigenin 7-O-(2G-rhaMnosyl)gentiobioside APIIN hydroxygenkwanin 5-[(β-D-Glucopyranosyl)oxy]-4',7-dihydroxyflavone 6-beta-D-Glucopyranosyl-8-beta-D-xylopyranosylapigenin Apigenin 6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranoside PONCIRIN Apigenin 7-glucoside BREVISCAPIN APIGENIN-7-GLUCURONIDE Neoisoliquiritin 7-HYDROXYFLAVONE-BETA-D-GLUCOSIDE Scutellarin VICENIN Apigenin-D5
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