ChemicalBook Product Catalog Biochemical Engineering Inhibitors Transmembrane Transporters Potassium Channel Inhibitors ML 133 Hydrochloride

ML 133 Hydrochloride

ML 133 Hydrochloride Basic information
Product Name:ML 133 Hydrochloride
Synonyms:(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;ML 133 Hydrochloride;1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride;CID 781301 hydrochloride;N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride (1:1);ML133 HCl;1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1);N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
CAS:1222781-70-5
MF:C19H20ClNO
MW:313.83
EINECS:
Product Categories:Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:1222781-70-5.mol
ML 133 Hydrochloride Structure
ML 133 Hydrochloride Chemical Properties
Melting point 193-195°C
storage temp. 2-8°C
solubility DMSO: ≥10mg/mL
form powder
color white to tan
Safety Information
Hazard Codes Xn,N
Risk Statements 22-37/38-41-50/53
Safety Statements 26-39-60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
MSDS Information
ML 133 Hydrochloride Usage And Synthesis
UsesML 133 is a selective inhibitor of inwardly rectifying Kir2.x potassium channels. ML 133 exhibits no effect on rKir1.1.
UsesML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.
Biological Activityml133 is a selective potassium channel inhibitor for kir2.1 with ic50 of 1.8 μm (ph 7.4) and 290 nm (ph 8.5), has no effect on kir1.1 and weak activity for kir4.1 and kir7.1.
Biochem/physiol ActionsML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.
storageStore at +4°C
ML 133 Hydrochloride Preparation Products And Raw materials
Canertinib AZD5363 Entinostat Galeterone Lenalidomide N,N-Dimethylbenzylamine 3-METHYLADENINE
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