Wnt-C59

Wnt-C59 Basic information
Product Name:Wnt-C59
Synonyms:Wnt-C59;2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide;C59;Wnt-C59 (C59);4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide;4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59;Wnt-C59, >=98%;WNT-C59 (C59);WNT C59;C59
CAS:1243243-89-1
MF:C25H21N3O
MW:379.45
EINECS:
Product Categories:Inhibitors;API
Mol File:1243243-89-1.mol
Wnt-C59 Structure
Wnt-C59 Chemical Properties
Melting point >159°C (dec.)
Boiling point 628.3±55.0 °C(Predicted)
density 1.198±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form Off-white powder
pka13.78±0.70(Predicted)
color Tan
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
HS Code 2933399990
MSDS Information
Wnt-C59 Usage And Synthesis
DescriptionWnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
UsesWnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
storage-20°C
References1) Proffitt et al. (2013), Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of Wnt-Driven Mammary Cancer; Cancer Res., 73 502 2) Koo et al. (2015), Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia; Proc. Natl. Acad. Sci.USA, 112 7548 3) Motono et al. (2016), Wnt-C59, a Small-Molecule Wnt Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells; Stem Cells Transl.Med., 5 552 4) Madan et al. (2016), Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis; Kidney Int., 89 1062
Wnt-C59 Preparation Products And Raw materials
PLX4032 WNT11 Antibody (aa136-185, HRP) LS-C441868 Wnt-7a (E-9) WNT2 / IRP Antibody LS-C393214 CHIR-99021 WS3 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenylbutane-1,4-dione Wnt-4 (B-6) Wnt-7a/b (H-8) Wnt-10a (A-4) WNT-3a, Human Recombinant Sunitinib Malate WWL229 xav-939 Y27632 (hydrochloride) Thiazovivin WY-14643 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.