ChemicalBook Product Catalog Biochemical Engineering Inhibitors Proteases Proteasome inhibitors (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Basic information
Product Name:(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
Synonyms:MLN2238;IxazoMib;(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid;IXAZOMIB;MLN 2238;MLN-2238;CS-1976;1-(2-(2,5-dichlorobenzamido)acetamido)- 3-methylbutylboronic acid;B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid;ixazomib(MLN2238)
CAS:1072833-77-2
MF:C14H19BCl2N2O4
MW:361.03
EINECS:810-246-8
Product Categories:Inhibitors;Inhibitor;apis
Mol File:1072833-77-2.mol
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Structure
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Chemical Properties
Melting point >142°C (subl.)
density 1.306
storage temp. -20°C Freezer
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka9.67±0.43(Predicted)
color White to Pale Yellow
Safety Information
MSDS Information
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Usage And Synthesis
UsesIxazomib is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.
DefinitionChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixa omib citrate, it is used in combination therapy for treatment of multiple myeloma.
targetchymotrypsin-like proteolytic (β5) site of the 20S proteasome
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Preparation Products And Raw materials
3-Formyl-2-nitrobenzoic acid methyl ester CHEMBRDG-BB 7959525 AC480 (BMS-599626) Brivanib alaninate CUDC-101 Carfilzomib 4-piperidin-3-ylaniline (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Dasatinib Piperidine, 3-(4-bromophenyl)- Oprozomib (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate MK-2206 2HCl Niraparib MLN9708 tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Bortezomib 1H-indazole-7-carboxylic acid
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