trans-Dichlorodiamineplatinum(II)

trans-Dichlorodiamineplatinum(II) Basic information

Product Name:	trans-Dichlorodiamineplatinum(II)
Synonyms:	trans-Diamminedichloroplatinum(II), Pt 64.5% min;trans-Diamminedichloroplatinum(II), trans-Dichlorodiammineplatinum(II);Transplatin (25 mg);trans-Dichlorodiamineplatinum(II)trans-DDPTransplatin;trans-DichlorodiaMineplatinuM(II), 99.95%, (trace Metal basis);LEDERPLATIN;BRIPLATIN;DIAMMINEDICHLOROPLATINATE (II)
CAS:	14913-33-8
MF:	Cl2H4N2Pt
MW:	298.03
EINECS:	238-980-9
Product Categories:	Anticancer;metal-ammine complexes;chemical reaction,pharm,electronic,materials;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Materials Science;Metal and Ceramic Science;Platinum Salts;Salts
Mol File:	14913-33-8.mol

trans-Dichlorodiamineplatinum(II) Chemical Properties

Melting point	340 °C (dec.)(lit.)
storage temp.	2-8°C
solubility	DMSO (Sparingly)
form	crystalline
color	yellow
Water Solubility	Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.
Exposure limits	ACGIH: TWA 0.002 mg/m3 NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3
EPA Substance Registry System	Platinum, diamminedichloro-, (SP-4-1)- (14913-33-8)

Safety Information

Hazard Codes	T,Xn
Risk Statements	45-25-41-68-42/43-40-23/24/25
Safety Statements	53-26-39-45-36/37-24-23
RIDADR	UN 3288 6.1/PG 2
WGK Germany	3
RTECS	TP2455000
F	10-21
HazardClass	6.1(a)
PackingGroup	II
HS Code	28439000
Hazardous Substances Data	14913-33-8(Hazardous Substances Data)
Toxicity	mouse,LD50,intraperitoneal,27mg/kg (27mg/kg),Chemico-Biological Interactions. Vol. 5, Pg. 415, 1972.

MSDS Information

Provider	Language
trans-Diammineplatinum(II) dichloride	English
ACROS	English
SigmaAldrich	English
ALFA	English

trans-Dichlorodiamineplatinum(II) Usage And Synthesis

Chemical Properties	Yellow Powder or Crystal
Uses	Transplatin is the trans stereoisomer impurity of trans-Dichlorodiamineplatinum(II), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
Uses	Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
Definition	ChEBI: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion. Unlike its cis-isomer, cisplatin, it does not exhibit any useful pharmacological effect and is toxic.
Safety Profile	Poison by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. See also PLATINUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx and Cl-.

trans-Dichlorodiamineplatinum(II) Preparation Products And Raw materials

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