(-)-3-Demethylcolchicine

(-)-3-Demethylcolchicine Basic information
Product Name:(-)-3-Demethylcolchicine
Synonyms:(-)-3-Demethylcolchicine;(S)-7-Acetylamino-6,7-dihydro-3-hydroxy-1,2,10-trimethoxybenzo[a]heptalen-9(5H)-one;3-Demethylcolchicine;3-O-Demethylcolchicine;3-DesMethylcolchicine;N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-triMethoxy-9-oxobenzo[a]heptalen-7-yl]-acetaMide;N-[[(7S)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene]-7α-yl]acetamide;O3-Demethylcolchicine
CAS:7336-33-6
MF:C21H23NO6
MW:385.41
EINECS:
Product Categories:Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:7336-33-6.mol
(-)-3-Demethylcolchicine Structure
(-)-3-Demethylcolchicine Chemical Properties
Melting point 163-166°C
Boiling point 768.3±60.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO : 100 mg/mL (259.46 mM; Need ultrasonic)
form A solid
pka9.53±0.40(Predicted)
Safety Information
ToxicityLD50 intraperitoneal in mouse: 570ug/kg
MSDS Information
(-)-3-Demethylcolchicine Usage And Synthesis
Chemical PropertiesYellow Solid
UsesA metabolite of Colchicine (C640000). Has shown anti-tumor activity.
(-)-3-Demethylcolchicine Preparation Products And Raw materials
Colchicine

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