N,N'-Bis(phenylmethyl)-1,2-ethanediamine

N,N'-Bis(phenylmethyl)-1,2-ethanediamine Basic information

Product Name:	N,N'-Bis(phenylmethyl)-1,2-ethanediamine
Synonyms:	N,N'-DIBENZYLETHYLENEDIAMINE;N'N-DIBENZYL-ETHYLENEDIAMINE;1,2-di(benzylamino)ethane;Benzathine~1,2-Bis(benzylamino)ethane;N,N`-dibenzylethylendiamine;BENZATHINE 99%;1 2-BIS(BENZYLAMINO)ETHANE 99%;1,2-ETHANEDIAMINE,N,N''-BIS(PHENYLMETHYL)-
CAS:	140-28-3
MF:	C16H20N2
MW:	240.34
EINECS:	205-408-4
Product Categories:	Nitrogen Compounds;Organic Building Blocks;Polyamines
Mol File:	140-28-3.mol

N,N'-Bis(phenylmethyl)-1,2-ethanediamine Chemical Properties

Melting point	23-25°C
Boiling point	195 °C4 mm Hg(lit.)
density	1.02 g/mL at 25 °C(lit.)
refractive index	n20/D 1.565(lit.)
Fp	>230 °F
storage temp.	Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Water (Slightly)
form	Solid
pka	9.15±0.19(Predicted)
color	White to Off-White
Specific Gravity	1.025
Water Solubility	Slightly soluble in water.
FreezingPoint	21.0 to 25.0 ℃
Sensitive	Air Sensitive
Merck	14,1064
BRN	786668
CAS DataBase Reference	140-28-3(CAS DataBase Reference)
NIST Chemistry Reference	1,2-Ethanediamine, N,N'-bis(phenylmethyl)-(140-28-3)
EPA Substance Registry System	1,2-Ethanediamine, N,N'-bis(phenylmethyl)- (140-28-3)

Safety Information

MSDS Information

Provider	Language
N,N'-Bis(phenylmethyl)-1,2-ethanediamine	English
SigmaAldrich	English
ALFA	English

N,N'-Bis(phenylmethyl)-1,2-ethanediamine Usage And Synthesis

Chemical Properties	light yellow liquid
Uses	N,N'-Dibenzylethylenediamine is an intermediate of cephalosporin and penicillin.
Definition	ChEBI: Benzathine is a diamine. It is a conjugate base of a benzathine(1+).
Synthesis Reference(s)	The Journal of Organic Chemistry, 55, p. 3209, 1990 DOI: 10.1021/jo00297a042
Safety Profile	Poison by ingestion,intraperitoneal, and parenteral routes. When heated todecomposition it emits toxic vapors of NOx.
Purification Methods	Dissolve DBED in acid, extract with toluene, basify, extract it with Et2O, dry over solid KOH, evaporate and fractionate it in vacuo. The diacetate crystallises from H2O by addition of EtOH and has m 111o (solubility in H2O is ~25%). The dihydrochloride has m 306-308o (from H2O) and the dipicrate has m 212o(dec) (from H2O). [Frost et al., J Am Chem Soc 71 3842 1949, Beilstein 12 H 1067, 12 III 2304.]

N,N'-Bis(phenylmethyl)-1,2-ethanediamine Preparation Products And Raw materials

Preparation Products

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