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| | Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Basic information |
| | Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Chemical Properties |
| Boiling point | 100.1℃ at 101.325kPa | | density | d20 1.19 | | vapor pressure | 0.003-17Pa at 20-45℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Soluble), DMSO (Slightly), Methanol (Slightly), Water | | form | Liquid | | PH | 3.43 at 20℃ and 10g/L | | LogP | -0.34-0.81 at 10-30℃ and pH5-9 | | Surface tension | 72.6-73mN/m at 1-1.106g/L and 19.5-20℃ | | Dissociation constant | 2.81-4.2 at 20-25℃ | | EPA Substance Registry System | 5-Chloro-2-methyl-3(2H)-isothiazolone mixt. with 2-methyl-3(2H)-isothiazolone (55965-84-9) |
| Toxicity | LD50 (mg/kg) orally in rabbits: 30; i.p. in male, female rats: 4.6, 4.3; LC50 (6 day) in trout, sunfish (mg/l): 0.14, 0.54; LC50 (8 day dietary) in Bobwhite quail, Peking duck (mg/kg/day): >60, >100 (J. Am. Coll. Toxicol.) |
| | Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Usage And Synthesis |
| Description | Kathon 886 metalwork fluid is a mixture of the two
isothiazoliones contained in Kathon CG, at a 13.9%
concentration. It is mainly contained in metalwork
fluids. As an active component of Aigezid Ⅱ and
contained in a water bath used for phtotographic
development, it caused contact dermatitis in a photograph
developer. | | Description | Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides. It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively. MCIT/MIT can elicit contact sensitization. Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products. | | Uses | Antimicrobial preservative in cosmetics, hygeine products, paints, emulsions, cutting oils, paper coatings, and water storage and cooling units. | | Hazard | A poison by ingestion. | | Contact allergens | Kathon? CG (CG = cosmetic grade) is a 3:1 mixture of CMI
and MI, at a 1.5% concentration. It is used for cosmetics and
toiletries, metalworking fluids or paints, in which it can be
added only periodically or in color film developers. Kathon?
886 MW (MW = metalworking fluids) is a mixture CMI/MI
mixture at a 13.9% concentration, mainly contained in metalworking
fluids. Kathon? FP 1.5 contains MCI/MI at 1.5%
concentration in propylene glycol. Kathon? LX (LX = LateX)
contains MCI/MI at a tenfold concentration of Kathon? CG.
Kathon? WT (WT = water treatment) is a MCI/MI mixture
used in the paper industry. Parmetol? K40, Parmethol? DF
12 and Parmetol? DF 35, Parmetol? A 23, Parmetol? K50,
and Parmetol? DF 18 are other brand names of MCI/MI. |
| | Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Preparation Products And Raw materials |
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